| Spectroscopic correlation analysis of NMR-based metabonomics in exercise science. | |
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MedLine Citation:
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PMID: 19786178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spectroscopic studies of complex clinical fluids have led to the application of a more holistic approach to their chemical analysis becoming more popular and widely employed. The efficient and effective interpretation of multidimensional spectroscopic data relies on many chemometric techniques and one such group of tools is represented by so-called correlation analysis methods. Typical of these techniques are two-dimensional correlation analysis and statistical total correlation spectroscopy (STOCSY). Whilst the former has largely been applied to optical spectroscopic analysis, STOCSY was developed and has been applied almost exclusively to NMR metabonomic studies. Using a (1)H NMR study of human blood plasma, from subjects recovering from exhaustive exercise trials, the basic concepts and applications of these techniques are examined. Typical information from their application to NMR-based metabonomics is presented and their value in aiding interpretation of NMR data obtained from biological systems is illustrated. Major energy metabolites are identified in the NMR spectra and the dynamics of their appearance and removal from plasma during exercise recovery are illustrated and discussed. The complementary nature of two-dimensional correlation analysis and statistical total correlation spectroscopy are highlighted. |
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Authors:
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Gemma M Kirwan; Vernon G Coffey; Julie O Niere; John A Hawley; Michael J Adams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-08 |
Journal Detail:
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Title: Analytica chimica acta Volume: 652 ISSN: 1873-4324 ISO Abbreviation: Anal. Chim. Acta Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-29 Completed Date: 2009-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370534 Medline TA: Anal Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 173-9 Citation Subset: IM |
Affiliation:
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Applied Chemistry, School of Applied Sciences, RMIT University, Melbourne, Vic., Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Automatic Data Processing Blood Chemical Analysis Exercise* Humans Metabolomics / methods* Nuclear Magnetic Resonance, Biomolecular / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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