Document Detail

Spectrophotometric and titrimetric determination of nizatidine in capsules.
MedLine Citation:
PMID:  12684116     Owner:  NLM     Status:  MEDLINE    
Four simple and accurate methods are described for the determination of nizatidine (NIZ) in pharmaceutical preparations. The first method is based on the formation of an ion-pair complex between the drug and either of bromocresol purple or picric acid with subsequent measurement of the developed colors at 411 and 400 nm, respectively. The second method depends on the condensation of mixed anhydrides of citric acid/acetic anhydride, with the tertiary amino group of the drug, where the developed color is measured spectrophotometrically at 545 nm. The oxidation of nizatidine by N-bromosuccinimide was utilized as a basis for the titrimetric method for its assay in capsules. The last method depends on the oxidation of nizatidine by ammonium cerium IV sulfate in the presence of perchloric acid with subsequent measurement of the absorbance at 314 nm; this principle is adopted to develop a kinetic method for the determination of NIZ in capsules. All the reaction conditions have been studied. The detection limits were varied from 0.44 to 0.78 microg ml(-1). The proposed methods were successfully applied to the assay of nizatidine in capsules.
F A El-Yazbi; Azza A Gazy; Hoda Mahgoub; M A El-Sayed; Rasha M Youssef
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  31     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-09     Completed Date:  2003-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  1027-34     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Elsevier Science B.V.
Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, University of Alexandria, El-Messalah, Alexandria 21521, Egypt.
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MeSH Terms
Acetic Anhydrides
Ammonium Sulfate
Citric Acid
Histamine H2 Antagonists / analysis*
Indicators and Reagents
Nizatidine / analysis*
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
0/Acetic Anhydrides; 0/Capsules; 0/Histamine H2 Antagonists; 0/Indicators and Reagents; 108-24-7/acetic anhydride; 76963-41-2/Nizatidine; 77-92-9/Citric Acid; 7783-20-2/Ammonium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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