Document Detail


Spectrophotometric study on the stability of dopamine and the determination of its acidity constants.
MedLine Citation:
PMID:  14583295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interest in determining the acidity constants of the catecholamines stems from the fact that they play rather an important biological role. The present work reveals the effect of different parameters such as oxygen, light, analysis time and pH on the dopamine oxidation process, where oxygen has an effect on the dopamine oxidation of 40% and up to 20% is attributed to exposure to light as a function of the pH. The application of adequate control on the said parameters (which ensured stability of the dopamine) facilitated the determination of the corresponding three acidity constants, 9.046+/-0.147, 10.579+/-0.148 and 12.071+/-0.069.
Authors:
A E Sánchez-Rivera; S Corona-Avendaño; G Alarcón-Angeles; A Rojas-Hernández; M T Ramírez-Silva; M A Romero-Romo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy     Volume:  59     ISSN:  1386-1425     ISO Abbreviation:  Spectrochim Acta A Mol Biomol Spectrosc     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-29     Completed Date:  2004-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9602533     Medline TA:  Spectrochim Acta A Mol Biomol Spectrosc     Country:  England    
Other Details:
Languages:  eng     Pagination:  3193-203     Citation Subset:  IM    
Affiliation:
Departamento de Qui;mica, Universidad Autónoma Metropolitana (Iztapalapa), Av. San Rafael Atlixco #186, Col. Vicentina, C.P. 09340, México, D.F., Mexico.
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MeSH Terms
Descriptor/Qualifier:
Dopamine / chemistry*
Drug Stability
Hydrogen-Ion Concentration*
Kinetics
Oxidation-Reduction
Spectrophotometry / methods

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