Document Detail


Spectrophotometric determination of tranexamic acid in pharmaceutical bulk and dosage forms.
MedLine Citation:
PMID:  16363487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, a simple, fast, accurate and sensitive spectrophotometric method has been developed for the determination of tranexamic acid in bulk and pharmaceutical preparations. The method is based on the reaction of ninhydrin with the primary amino group of tranexamic acid in the basic medium at pH 8.0. The reaction produces a bluish-purple color which absorbs maximally at 565 nm. Beer's law was obeyed in the range of 3-40 microg ml(-1) with molar absorptivity of 5.093 x 10(3) L mol(-1) cm(-1). The effects of various factors such as temperature, heating time, concentration of reagent, color stability and interferences were investigated to optimize the procedure. The results have been validated analytically and statistically. The proposed method has been applied for the determination of tranexamic acid in bulk and pharmaceutical preparations with good results.
Authors:
Tariq Mahmood Ansari; Asad Raza; Atta-ur Rehman
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry     Volume:  21     ISSN:  0910-6340     ISO Abbreviation:  Anal Sci     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-12-20     Completed Date:  2006-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511078     Medline TA:  Anal Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1133-5     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan. drtariq2000@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Dosage Forms
Molecular Structure
Ninhydrin / chemistry
Pharmaceutical Preparations / chemistry*
Reproducibility of Results
Sensitivity and Specificity
Spectrophotometry / methods
Time Factors
Tranexamic Acid / analysis*
Chemical
Reg. No./Substance:
0/Dosage Forms; 0/Pharmaceutical Preparations; 1197-18-8/Tranexamic Acid; 485-47-2/Ninhydrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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