| Spectrophotometric determination of tranexamic acid in pharmaceutical bulk and dosage forms. | |
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MedLine Citation:
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PMID: 16363487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, a simple, fast, accurate and sensitive spectrophotometric method has been developed for the determination of tranexamic acid in bulk and pharmaceutical preparations. The method is based on the reaction of ninhydrin with the primary amino group of tranexamic acid in the basic medium at pH 8.0. The reaction produces a bluish-purple color which absorbs maximally at 565 nm. Beer's law was obeyed in the range of 3-40 microg ml(-1) with molar absorptivity of 5.093 x 10(3) L mol(-1) cm(-1). The effects of various factors such as temperature, heating time, concentration of reagent, color stability and interferences were investigated to optimize the procedure. The results have been validated analytically and statistically. The proposed method has been applied for the determination of tranexamic acid in bulk and pharmaceutical preparations with good results. |
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Authors:
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Tariq Mahmood Ansari; Asad Raza; Atta-ur Rehman |
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Publication Detail:
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Type: Journal Article; Validation Studies |
Journal Detail:
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Title: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry Volume: 21 ISSN: 0910-6340 ISO Abbreviation: Anal Sci Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-12-20 Completed Date: 2006-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511078 Medline TA: Anal Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1133-5 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan. drtariq2000@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dosage Forms Molecular Structure Ninhydrin / chemistry Pharmaceutical Preparations / chemistry* Reproducibility of Results Sensitivity and Specificity Spectrophotometry / methods Time Factors Tranexamic Acid / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Dosage Forms; 0/Pharmaceutical Preparations; 1197-18-8/Tranexamic Acid; 485-47-2/Ninhydrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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