| Spectrophotometric determination of some histamine H1-antagonists drugs in their pharmaceutical preparations. | |
| | |
MedLine Citation:
|
PMID: 17553739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Two rapid, simple and sensitive extractive specrophotometric methods has been developed for the determination of three histamine H1-antagonists drugs, e.g., chlorphenoxamine hydrochloride (CPX), diphenhydramine hydrochloride (DPH) and clemastine (CMT) in bulk and in their pharmaceutical formulations. The first method depend upon the reaction of molybdenum(V) thiocyanate ions (Method A) with the cited drugs to form stable ion-pair complexes which extractable with methylene chloride, the orange red color complex was determined colorimetrically at lambda(max) 470nm. The second method is based on the formation of an ion-association complex with alizarin red S as chromogenic reagents in acidic medium (Method B), which is extracted into chloroform. The complexes have a maximum absorbance at 425 and 426nm for (DPH or CMT) and CPX, respectively. Regression analysis of Beer-Lambert plots showed a good correlation in the concentration ranges of 5.0-40 and 5-70microgmL(-1) for molybdenum(V) thiocyanate (Method A) and alizarin red S (Method B), respectively. For more accurate analysis, Ringbom optimum concentration ranges were calculated. The molar absorptivity, Sandell sensitivity, detection and quantification limits were calculated. Applications of the procedure to the analysis of various pharmaceutical preparations gave reproducible and accurate results. Further, the validity of the procedure was confirmed by applying the standard addition technique and the results obtained in good agreement well with those obtained by the official method. |
| | |
Authors:
|
Wafaa S Hassan; Magda M El-Henawee; Ayman A Gouda |
Related Documents
:
|
9158239 - Direct determination of amiloride in urine using isopotential fluorimetry. 18966619 - Long-wavelength stopped-flow fluorimetric determination of lysozyme. 23141709 - Thermal solid sample introduction-fast gas chromatography-low flow ion mobility spectro... 18965599 - Fia-ft-ir determination of ibuprofen in pharmaceuticals. 11522129 - Quantitative analysis of the elemental composition and the mass of bacterial polyphosph... 19615529 - Reversed flow injection spectrophotometric determination of chlorate. 22688049 - Determination of total polyphenol index in wines employing a voltammetric electronic to... 19488689 - Hplc-chip/ms technology in proteomic profiling. 15899569 - Determination of roxithromycin in rat lung tissue by liquid chromatography-mass spectro... |
Publication Detail:
|
Type: Journal Article Date: 2007-03-31 |
Journal Detail:
|
Title: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Volume: 69 ISSN: 1386-1425 ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Publication Date: 2008 Jan |
Date Detail:
|
Created Date: 2007-12-24 Completed Date: 2008-04-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602533 Medline TA: Spectrochim Acta A Mol Biomol Spectrosc Country: England |
Other Details:
|
Languages: eng Pagination: 245-55 Citation Subset: IM |
Affiliation:
|
Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anthraquinones
/
chemistry Clemastine / analysis, chemistry, isolation & purification Diphenhydramine / analysis, chemistry, isolation & purification Dosage Forms Ethylamines / analysis, chemistry, isolation & purification Histamine H1 Antagonists / analysis*, chemistry, isolation & purification Hydrogen-Ion Concentration Kinetics Pharmaceutical Preparations / chemistry* Reproducibility of Results Solvents / chemistry Spectrophotometry Temperature Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Anthraquinones; 0/Dosage Forms; 0/Ethylamines; 0/Histamine H1 Antagonists; 0/Pharmaceutical Preparations; 0/Solvents; 15686-51-8/Clemastine; 58-73-1/Diphenhydramine; 77-38-3/chlorphenoxamine; 83-61-4/Alizarin Red S |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: DFT and ab initio study of structure of dyes derived from 2-hydroxy and 2,4-dihydroxy benzoic acids.
Next Document: Development and evaluation of SYBR Green I-based one-step real-time RT-PCR assay for detection and q...