Document Detail

Spectrophotometric determination of acidity constants of 4-dedimethylamino sancycline (Col-3), a new antitumor drug.
MedLine Citation:
PMID:  10229645     Owner:  NLM     Status:  MEDLINE    
A spectrophotometric technique was used to determine the acidity constants of 4-dedimethylamino sancycline (Col-3), a new antitumor drug. The apparent pKa values of Col-3 in 0.5% methanol aqueous media at approximately 25 degrees C with a constant ionic strength of 0.2 were calculated manually and graphically to be 5.64 +/- 0.17 (pKa1) and 8.35 +/- 0.07 (pKa2). In addition, the computer program SQUAD was used to confirm Col-3 pKa values. The pKa values obtained by SQUAD were pKa1 5.63 +/- 0.14 and pKa2 8.39 +/- 0.04. These results are in agreement with the tetracycline-like structure of Col-3.
S Pinsuwan; F A Alvarez-Núñez; S E Tabibi; S H Yalkowsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  88     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-07     Completed Date:  1999-06-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  535-7     Citation Subset:  IM    
Department of Pharmaceutical Technology, Prince of Songkla University, Songkhla, Thailand.
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MeSH Terms
Antineoplastic Agents / chemistry*
Hydrogen-Ion Concentration
Tetracycline / chemistry*
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents; 0/Tetracyclines; 0/tetracycline CMT-3; 60-54-8/Tetracycline

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