Document Detail

Spectrophotometric analysis of melanocytic naevi during pregnancy.
MedLine Citation:
PMID:  17533489     Owner:  NLM     Status:  MEDLINE    
Malignant melanoma is the most common cancer during pregnancy, but it is unknown whether melanocytic naevi in general are activated. A total of 381 melanocytic naevi in 34 Caucasian primigravidae were examined using spectrophotometric intracutaneous analysis (SIAscopy) technology in early pregnancy and prior to delivery. The Siagraphs of each naevus were then compared in order to evaluate changes over time. A total of 163 melanocytic naevi in 21 nulliparous women served as an additional control group. At the first visit none of the Siagraphs examined for the case or control groups aroused suspicion of dysplastic naevus or melanoma and no significant structural changes were noted during the observation period. However, 2.1% of the melanocytic naevi in the pregnant group increased and 1.3% decreased in size. Corresponding figures in the non-pregnant group were 1.8% and 0%, respectively. Only one naevus in a pregnant woman increased slightly in epidermal pigmentation, and a decrease in pigmentation was noted in 3.7% of the melanocytic naevi in the cases and 1.8% in the controls. None of the differences within or between the groups was statistically significant. We conclude that pregnancy does not influence the appearance of pigmented naevi. A changing naevus during pregnancy should be examined carefully and considered for excision and histopathology.
Yvonne Wyon; Ingrid Synnerstad; Mats Fredrikson; Inger Rosdahl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  87     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-29     Completed Date:  2007-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  231-7     Citation Subset:  IM    
Division of Dermatology, University Hospital, University of Linköping, Linköping, Sweden.
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MeSH Terms
Case-Control Studies
Collagen / metabolism
Melanins / metabolism
Nevus, Pigmented / blood supply,  metabolism,  pathology*
Pregnancy Complications, Neoplastic / metabolism,  pathology*
Skin Neoplasms / blood supply,  metabolism,  pathology*
Reg. No./Substance:
0/Melanins; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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