Document Detail


Spectrofluorimetric study of the interaction of ciprofloxacin with amino acids in aqueous solution following solvatochromic studies.
MedLine Citation:
PMID:  22516117     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Complexation of a fluoroquinolone derivative (ciprofloxacin), L, and some amino acids has been studied using spectrofluorimetric method. Results indicated that ciprofloxacin have a greater tendency to form a 1:1 complex with aspartic acid and arginine than the other tested molecules. The fluorescence of ciprofloxacin exhibits quenching process while it has been titrated with these amino acids. Formation constant values (K(f)) for complex formed between ciprofloxacin and amino acids were also calculated. Thermodynamic parameters such as ΔG°, ΔH° and ΔS° were studied too. Possible reasons for the observed stability sequence were discussed based on the structures proposed for the resulting complexes. Besides the solution studies, solvatochromic properties of the ciprofloxacin are discussed by studying its spectra in a selection of different solvents.
Authors:
Kamal Alizadeh; Mahsa Mobarrez; Mohammad Reza Ganjali; Parviz Norouzi; Mohammad Javad Chaichi
Related Documents :
1694787 - Transforming growth factor-beta and epidermal growth factor modulate basal and interleu...
6434537 - The biosynthesis of hypusine (n epsilon-(4-amino-2-hydroxybutyl)lysine). alignment of t...
9281827 - In vitro 14c-amino acid fermentation by cf3, a characterized continuous-flow competitiv...
6268567 - Structural proteins and glycoproteins of infectious bronchitis virus particles labeled ...
12928887 - Synergistic effects of pyrantel and the febantel metabolite fenbendazole on adult toxoc...
18083017 - Stearic acid potently modulates the activity of cyclooxygenase-1, but not cyclooxygenas...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-29
Journal Detail:
Title:  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy     Volume:  94C     ISSN:  1873-3557     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602533     Medline TA:  Spectrochim Acta A Mol Biomol Spectrosc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  72-77     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Department of Chemistry, Lorestan University, Khorramabad, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Crystal structure, spectra properties and comparative studies on a 2-pyrazoline derivative.
Next Document:  Growth, spectroscopy, dielectric and nonlinear optical studies of novel organic NLO crystal: l-Threo...