Document Detail


Spectral tuning of the long wavelength-sensitive cone pigment in four Australian marsupials.
MedLine Citation:
PMID:  16859843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The molecular basis for the spectral tuning of longwave-sensitive (LWS) visual pigments in mammals have been described in a wide range of placental species, including the primates. However, little is known about the molecular mechanisms in marsupial LWS pigments. Here, we have studied and compared the LWS opsins in four Australian marsupials: two diprotodonts and two polyprotodonts. Phylogenetic analysis establishes that all LWS marsupial sequences form a distinct clade from the placental mammals that is subdivided into diprotodont and polyprotodont groups. Amino acid sequences reveal that substitutions at sites 277 and 285 are largely responsible for the spectral shifts in marsupial LWS pigments and species comparison indicates that the ancestral gene most likely encoded Tyr277 and Ala180. Amino acid substitutions are discussed in the context of spectral shifts in marsupial LWS and in relation to the mechanisms in primate pigments.
Authors:
Catherine A Arrese; Lyn D Beazley; Margo C Ferguson; Alison Oddy; David M Hunt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-21
Journal Detail:
Title:  Gene     Volume:  381     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2006-11-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  13-7     Citation Subset:  IM    
Affiliation:
School of Animal Biology-WAIMR University of Western Australia, Crawley, WA 6009, Australia. carrese@cyllene.uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Amino Acid Substitution
Animals
Australia
Base Sequence
Cloning, Molecular
Evolution, Molecular
Marsupialia / physiology*
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
RNA, Messenger / genetics,  metabolism
Retinal Cone Photoreceptor Cells / chemistry*
Rod Opsins / chemistry*,  genetics
Sequence Homology, Amino Acid
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Rod Opsins; 0/long-wavelength opsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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