| Spectral resolution amelioration by deconvolution (SPREAD) in MR spectroscopic imaging. | |
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MedLine Citation:
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PMID: 19472414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To develop, implement, and evaluate a novel postprocessing method for enhancing the spectral resolution of in vivo MR spectroscopic imaging (MRSI) data. MATERIALS AND METHODS: Magnetic field inhomogeneity across the imaging volume was determined by acquiring MRI datasets with two differing echo times. The lineshapes of the MRSI spectra were derived from these field maps by simulating an MRSI scan of a virtual sample whose resonance frequencies varied according to the observed variations in the magnetic field. By deconvolving the lineshapes from the measured MRSI spectra, the linebroadening effects of the field inhomogeneities were reduced significantly. RESULTS: Both phantom and in vivo proton MRSI spectra exhibited significantly enhanced spectral resolutions and improved spectral lineshapes following application of our method. Quantitative studies on a phantom show that, on average, the full width at half maximum of water peaks was reduced 42%, the full width at tenth maximum was reduced 38%, and the asymmetries of the peaks were reduced 86%. CONCLUSION: Our method reduces the linebroadening and lineshape distortions caused by magnetic field inhomogeneities. It substantially improves the spectral resolution and lineshape of MRSI data. |
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Authors:
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Zhengchao Dong; Bradley S Peterson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 29 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-07-29 Revised Date: 2010-09-24 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1395-405 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Columbia University College of Physicians & Surgeons, New York, NY, USA. dongzh@childpsych.columbia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aspartic Acid
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analogs & derivatives,
metabolism Brain / anatomy & histology, metabolism Brain Mapping / methods* Choline / metabolism Creatine / metabolism Humans Image Enhancement / methods* Image Processing, Computer-Assisted / methods* Magnetic Resonance Spectroscopy / methods* Phantoms, Imaging |
| Grant Support | |
ID/Acronym/Agency:
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DA017820/DA/NIDA NIH HHS; K02-74677//PHS HHS; MH068318/MH/NIMH NIH HHS; MH36197/MH/NIMH NIH HHS; R01 MH068318-05/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
| Comments/Corrections | |
Erratum In:
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J Magn Reson Imaging. 2009 Sept;30(3):697 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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