Document Detail

Spectral pulsed Doppler sonography of renal vascular resistance in sickle cell disease: clinical implications.
MedLine Citation:
PMID:  9135467     Owner:  NLM     Status:  MEDLINE    
The major complications in sickle cell disease (SCD) are microcirculation lesions and impairment of renal function. The aim of this study was the evaluation of renal vascular resistance by means of spectral pulsed Doppler sonography and its relationships with haematological and clinical features in patients with SCD. 40 patients with SCD (mean age 22.4 +/- 7.0) and 14 age and sex matched healthy subjects (mean age 25.7 +/- 9.5) were included into the study. Spectral Doppler sonography of main renal, segmental and interlobar arteries were performed on both kidneys in all patients and controls. Peak systolic, end diastolic and mean velocities through the entire cardiac cycle were obtained, with calculation of the resistive (RI) and pulsatility (PI) indices. All the patients were investigated in stable state conditions and had not been transfused within a month before investigation. Patients were followed for up to 6 months. Patients with SCD had higher values of RIs and PIs than control subjects (p < 0.0001, p < 0.0001, respectively). Patients with high value of RIs (RI > 0.70) had more pronounced disturbances of blood parameters (all p < 0.05), than patients with normal RIs (RI < 0.70). Significant positive correlation existed between RIs and ISC number, MCHC level (r = 0.52, p < 0.001 and r = 0.42, p < 0.01), while RBC count and Hb level correlated inversely with RIs (r = -0.39, p < 0.01 and r = -0.42, p < 0.01). During follow-up, nine patients (33.3%) with high RIs and only one patient (5.5%) with normal RI developed painful crises. In conclusion, renal vascular resistance, assessed by Doppler sonography was raised in SCD patients as compared with age matched apparently healthy persons. These changes were more pronounced in those with more severe manifestations of disease and correlated with haematological and clinical features of sickle cell disease.
K S Aikimbaev; M Oğuz; B Güvenç; F Başlamişli; R Koçak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of radiology     Volume:  69     ISSN:  0007-1285     ISO Abbreviation:  Br J Radiol     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-05-19     Completed Date:  1997-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1125-9     Citation Subset:  AIM; IM    
Department of Radiology, Balcali Hospital, Cukurova University, Medical Faculty, Adana, Turkey.
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MeSH Terms
Case-Control Studies
Hemoglobins / analysis
Kidney / blood supply*,  ultrasonography
Renal Artery / physiopathology,  ultrasonography
Sickle Cell Trait / physiopathology*,  ultrasonography
Ultrasonography, Doppler, Pulsed
Vascular Resistance*
Reg. No./Substance:

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