| Spectral karyotyping reveals 17;22 fusions in a cytogenetically atypical dermatofibrosarcoma protuberans with a large marker chromosome as a sole abnormality. | |
| | |
MedLine Citation:
|
PMID: 11319805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The presence of an extra ring chromosome containing material from 17q and 22q, or, less frequently, a t(17;22)(q22;q13), is a cytogenetic hallmark of dermatofibrosarcoma protuberans (DFSP). However, occasionally tumors with other, atypical karyotypes are encountered. We describe a case of recurrent DFSP without a ring chromosome or a t(17;22) on standard cytogenetic analysis. In all cells analyzed by G-banding, an additional, large marker chromosome was present as a sole abnormality. This chromosome apparently included chromosome 8 or the 8q arm, but the origin of its remaining part could not be determined with certainty. To characterize further the abnormal chromosome, we applied spectral karyotyping (SKY). SKY confirmed the presence of an extra chromosome 8 or arm 8q in the marker and showed that its remaining part was composed of segments from chromosomes 7, 17, 21, and 22, with two copies of a 17;22 fusion. Our results and the literature data suggest that, in addition to a specific 17;22 fusion, amplification of material from chromosomes 17, 22, 8, 5, 7, and 21 may play a role in DFSP development and/or progression. Furthermore, our case demonstrates the usefulness of SKY in detection of a diagnostically relevant 17;22 fusion in DFSP patients who have unusual karyotypic features. |
| | |
Authors:
|
K Mrózek; M Iliszko; J Ryś; M Babińska; A Niezabitowski; C D Bloomfield; J Limon |
Related Documents
:
|
11499845 - Molecular cytogenetic analysis of two primary squamous cell carcinomas of the lung usin... 12368185 - Identification of chromosome 9 alterations and p53 accumulation in isolated carcinoma i... 1933825 - Cytogenetic analysis of primary neuroblastoma with del(1), del(14), hsr, and dmin chrom... 9166285 - Interphase cytogenetic analysis of mucinous ovarian neoplasms. 14511405 - Induction of chromosomal instability by chronic oxidative stress. 15856695 - Experimental studies of adaptation in clarkia xantiana. ii. fitness variation across a ... |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Genes, chromosomes & cancer Volume: 31 ISSN: 1045-2257 ISO Abbreviation: Genes Chromosomes Cancer Publication Date: 2001 Jun |
Date Detail:
|
Created Date: 2001-04-25 Completed Date: 2001-07-12 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9007329 Medline TA: Genes Chromosomes Cancer Country: United States |
Other Details:
|
Languages: eng Pagination: 182-6 Citation Subset: IM |
Copyright Information:
|
Copyright 2001 Wiley-Liss, Inc. |
Affiliation:
|
Division of Hematology and Oncology, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA. mrozek-1@medctr.osu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Chromosome Painting Chromosomes, Human, Pair 17 / genetics* Chromosomes, Human, Pair 22 / genetics* Chromosomes, Human, Pair 8 / genetics Dermatofibrosarcoma / genetics* Female Genetic Markers / genetics Humans Karyotyping / methods Neoplasm Recurrence, Local Ring Chromosomes Skin Neoplasms / genetics* Translocation, Genetic / genetics* |
| Grant Support | |
ID/Acronym/Agency:
|
5P30CA16058/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Genetic Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Three chromosomal rearrangements in neuroblastoma cluster within a 300-kb region on 1p36.1.
Next Document: Coduplication of the MLL and FLT3 genes in patients with acute myeloid leukemia.