| Spectral characteristics of heart rate and blood pressure variability in primary aldosteronism. | |
| | |
MedLine Citation:
|
PMID: 7662224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A disturbance of the autonomic cardiovascular function has been postulated in primary aldosteronism as a possible mechanism for hypertension. Using the method of spectral analysis of heart rate and blood pressure variability, the aim of this study was to assess sympathovagal interactions modulating cardiovascular function and baroreflex control in patients with primary aldosteronism. Seventeen patients (7 with adenomas and 10 with idiopathic hyperaldosteronism) and a control group of 11 essential hypertensives (EH) and 10 normotensive subjects were studied. Continuous finger blood pressure was measured using a Finapres device and heart rate was measured using an electrocardiographic monitor. The studies were conducted in each patient for 20 min in the supine position and 10 min during a passive head-up tilt to 60 degrees. The low frequency and the low frequency-to-high frequency ratio of systolic and diastolic blood pressures were significantly higher both in primary aldosteronism and in EH patients compared with normotensives (P < .01). Impaired response to tilt was found in the heart rate and blood pressure variability in primary aldosteronism and EH patients; the increase in low frequency was smaller than in normotensives. Baroreflex gain (assessed by alpha index) was less in primary aldosteronism and EH patients as compared with normotensives. These findings may suggest that volume expansion or sympathetically mediated central translocation of the blood volume, or both, could stimulate the cardiopulmonary receptors and impair the baroreflex gain. Our findings suggest that an enhanced peripheral vascular responsiveness to a normal sympathetic outflow may be involved in the pathogenesis of hypertension in primary aldosteronism. |
| | |
Authors:
|
F Veglio; R Melchio; F Rabbia; P Molino; G Martini; L Chiandussi |
Related Documents
:
|
9854594 - Essential hypertension: first reason for persistent hypertension after unilateral adren... 3084274 - Angiotensin ii, aldosterone and arginine vasopressin in plasma in congestive heart fail... 2442774 - Autometrically and automatically monitored, iatrogenous, inhalant-decongestant-associat... 19863864 - Characterization and treatment of resistant hypertension. 10658034 - Effects of positive end-expiratory pressure ventilation on cerebral venous pressure wit... 2132424 - Efficacy and tolerance of nisoldipine vs propranolol in patients with essential hyperte... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: American journal of hypertension Volume: 8 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1995 May |
Date Detail:
|
Created Date: 1995-10-12 Completed Date: 1995-10-12 Revised Date: 2009-02-24 |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 479-86 Citation Subset: IM; S |
Affiliation:
|
Department of Medicine and Experimental Oncology, University of Turin, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Baroreflex
/
physiology Blood Pressure / physiology* Blood Pressure Determination Cardiovascular System / innervation Electrocardiography Female Heart Rate / physiology* Humans Hyperaldosteronism / etiology, physiopathology* Male Middle Aged Regression Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic influences on ambulatory blood pressure patterns. The Medical College of Virginia Twin Study...
Next Document: Effect of antihypertensive treatment on the increased beta 2-adrenoceptor density in patients with e...