| Spectral analysis of laser Doppler skin blood flow oscillations in human essential arterial hypertension. | |
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MedLine Citation:
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PMID: 16797604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate whether human essential arterial hypertension (EHT) is associated with modification of the skin blood flowmotion (SBF), which could be a sign of skin microcirculatory impairment. Forearm skin perfusion was measured by laser Doppler flowmetry (LDF) in conventional perfusion units (PU) before and after ischemia in 20 middle-age newly diagnosed EHT untreated patients, in 20 middle-age long standing EHT treated patients and in 30 age and sex matched healthy normotensive subjects (NS). Power spectral density (PSD) of SBF total spectrum (0.009-1.6 Hz), as well of five different frequency intervals (FI), each of them related to endothelial (0.009-0.02 Hz), sympathetic (0.02-0.06 Hz), myogenic (0.06-0.2 Hz), respiratory (0.2-0.6) or cardiac (0.6-1.6) activity, was also measured in PU(2)/Hz before and after ishemia, using Fourier analysis of LDF signal. The three studied groups did not differ in basal and post-ischemic skin perfusion or in basal SBF parameters considered. However, while a significant post-ischemic increase in PSD of total spectrum SBF (P < 0.001) and of its different FI, with the only exception of respiratory FI, was observed in NS, a significsnt post-ischemic increase in PSD was observed only for total spectrum (P < 0.01) and for endothelial FI (P < 0.001) in newly diagnosed EHT patients and only for myogenic FI (P < 0.05) in long standing EHT patients. These findings suggest that the mechanisms which mediate the post-ischemic increment of SBF are perturbed earlier in human EHT than the mechanisms which mediate the skin post-ischemic hyperaemia. The same findings also suggest that the impairment of the endothelial mechanism involved in SBF control occurs by the time in the course of EHT. |
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Authors:
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Marco Rossi; Angelo Carpi; Cinzia Di Maria; Fabio Galetta; Gino Santoro |
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Publication Detail:
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Type: Journal Article Date: 2006-06-22 |
Journal Detail:
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Title: Microvascular research Volume: 72 ISSN: 0026-2862 ISO Abbreviation: Microvasc. Res. Publication Date: 2006 Jul-Sep |
Date Detail:
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Created Date: 2006-08-01 Completed Date: 2007-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0165035 Medline TA: Microvasc Res Country: United States |
Other Details:
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Languages: eng Pagination: 34-41 Citation Subset: IM |
Affiliation:
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University of Pisa, mrossi@int.med.unipi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity Case-Control Studies Diagnostic Techniques, Cardiovascular Female Humans Hypertension / blood*, diagnosis* Laser-Doppler Flowmetry / methods* Male Microcirculation Middle Aged Oscillometry Regional Blood Flow Skin / blood supply*, pathology |
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