Document Detail


Spectral analysis of intercycle heart fluctuations in the diethyl-ether-anaesthetized or pithed rat treated with prazosin, dl-propranolol, endothelin-1, alpha-r atriopeptin and ACE-inhibitors.
MedLine Citation:
PMID:  9831227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Frequency-domain spectral analysis of stationary ECG R-R intervals was made by fast Fourier transformation (FFT) in conditions of monitored arterial blood pressure and respiratory activity in diethyl-ether-anaesthetized and pithed adult rats. This technique yields a number of parameters which allow quantitative evaluation of the non-random distribution of the mean values obtained in time-domain studies. The frequency-analysis method enables the overall heart rate variability to be broken down into its various constituents, which are differently affected by physiological loading and capable of selective reactivity to pharmacological agents. 2. The low-frequency spectral component obtained by breaking down the total spectral density power, i.e. the appropriate variability signal (band width < 0.15 Hz) and a higher-frequency band corresponding to spontaneous (0.80-1.60 Hz) or artificially imposed (0.75 Hz) respiratory activity were estimated and their integrated areas evaluated as absolute powers or normalized fractional values. 3. The power of the high-frequency spectral component increased in all animal preparations under treatment with prazosin, dl-propranolol, endothelin-1 and the angiotensin converting enzyme (ACE) inhibitors captopril, lisinopril, quinapril and ramipril. The power of the low-frequency band increased under alpha-r atriopeptin and ACE inhibitors in the pithed preparations only, and decreased in the anaesthetized animals. 4. The new power spectrum features and trends detected indicate that these time-independent, model-dependent cardiovascular and respiratory markers are subject to some form of complex peptidergic control. 5. The relative roles of the various factors operating in the genesis of these short-term changes in spectral power in the low- and high-frequency bands cannot be interpreted as indicating a reciprocal push-pull relationship between sympathetic and parasympathetic control. 6. The study findings, however, can be interpreted as providing evidence of a different and to some extent alternative form of integrative cardiovascular control persisting in the pithed rats (i.e. in the 'peripheral', CNS-destroyed preparations). 7. New areas of theoretical and applied research are being developed in the (auto)classification of (iso)receptors and drug analogues through exploration of multiple physiological and pharmacokinetic parameters in the frequency-domain. Furthermore, model-independent frequency-domain methods not requiring stationary data will afford scope for even more significant developments by separating the overlapping dynamic processes from a whole series of correlated effects.
Authors:
M Bernardi; R Deslauriers; J Docherty; C Rossi; L Rossini; P Rossini; C Tonnini
Related Documents :
8582447 - Assessment of cardiac autonomic control by heart period variability in patients with ea...
16446677 - Characterization of arm-gun movement during air pistol aiming phase.
10765987 - Physiological tremor: does handedness make a difference?
19965157 - Empirical mode decomposition (emd) analysis of hrv data from locally anesthetized patie...
9893817 - Global induced motion and visual stability in an optic flow illusion.
23209127 - Gene regulation of carbon fixation, storage and utilization in the diatom phaeodactylum...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autonomic pharmacology     Volume:  18     ISSN:  0144-1795     ISO Abbreviation:  J Auton Pharmacol     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-02-04     Completed Date:  1999-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106455     Medline TA:  J Auton Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  271-80     Citation Subset:  IM    
Affiliation:
I.M.O. - Institute of Experimental and Clinical Medicine, University of Ancona Medical School, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Natriuretic Factor / pharmacology*
Electrocardiography / methods
Endothelin-1 / pharmacology*
Ether, Ethyl / pharmacology
Female
Heart Rate / drug effects*
Male
Prazosin / pharmacology*
Propranolol / pharmacology*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Endothelin-1; 19216-56-9/Prazosin; 525-66-6/Propranolol; 60-29-7/Ether, Ethyl; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The offset of beta-adrenoceptor antagonism of the responses of the rat right ventricle to isoprenali...
Next Document:  Involvement of nitric oxide in the mediation of NANC inhibitory neurotransmission of guinea-pig trac...