Document Detail

Spectral analysis of heart rate variability in patients with Machado-Joseph disease.
MedLine Citation:
PMID:  20060786     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Tachycardia is a clinical feature of Machado-Joseph disease (MJD), and it may be attributable to cardiac autonomic dysfunction. We investigated heart rate variability in MJD patients to reveal heart rate dysregulation in MJD. METHODS: Power spectral analysis of successive R-R intervals (300 beats) was performed in 10 genetically diagnosed MJD patients and 10 healthy control subjects to obtain frequency-domain measures, including high- (HF; 0.15-0.4 Hz) and low frequency power (LF; 0.04-0.15 Hz) and the ratio of LF to HF (LF/HF) of heart rate variability. In addition, the coefficient of R-R intervals (CV(R-R)) was calculated as a time-domain measure. RESULTS: HF in the MJD patients (26.2+/-25.3 ms(2)) was lower than that in the controls (82.1+/-82.6 ms(2), p=0.004). LF was also lower in the MJD patients (70.6+/-69.4 ms(2)) than in the controls (106.9+/-81.3 ms(2); p=0.029). There was no significant difference in LF/HF or CV(R-R) between the groups. CONCLUSION: HF, which is modulated by parasympathetic vagal activity, was low in our MJD patients. The reduced parasympathetic activity may be a cause of tachycardia in MJD patients.
Masato Asahina; Akira Katagiri; Yoshitaka Yamanaka; Yuichi Akaogi; Takeshi Fukushima; Kazuaki Kanai; Satoshi Kuwabara
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Publication Detail:
Type:  Journal Article     Date:  2010-01-08
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  154     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  99-101     Citation Subset:  IM    
Copyright Information:
2009 Elsevier B.V. All rights reserved.
Department of Neurology, Chiba University School of Medicine, Chiba, Japan.
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MeSH Terms
Blood Pressure / physiology
Heart Rate / physiology*
Machado-Joseph Disease / genetics,  physiopathology*
Middle Aged
Spectrum Analysis / methods*
Tachycardia / etiology

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