Document Detail

Spectral Marker for C(α) Damage in Beta Peptides.
MedLine Citation:
PMID:  23301948     Owner:  NLM     Status:  Publisher    
The work in this article describes a spectral signature for the detection of a C(α) radical damaged peptide, which should enable the use of infrared spectroscopic methods to directly monitor oxidative events. Spectra for radical damaged peptides are computed with ab initio methods. The amide bands A, I, II, and III are analyzed for trends in the damage site. The spectral signature is found in a region (i.e., 1700-1620 cm(-1)) normally void of vibrational absorption bands from stable undamaged beta peptides. An analysis of the vibrational motions of the spectral signature is described. The uniqueness of the spectral signature is explored by an examination and comparison with C(α) monoradicals and polyradicals, as well as with other bioradicals that could act as spectral interferences. The identification of unique infrared spectral features for C(α) damage could have important implications in diagnostics for beta conformational peptides damaged by oxidative stress processes.
Mandy C Green; Sarah Stelzleni; Joseph S Francisco
Related Documents :
17929938 - Water-driven chemoselective reaction of squarate derivatives with amino acids and pepti...
12790518 - Organoplatinum(ii) complexes as a color biomarker in solid-phase peptide chemistry and ...
24714498 - Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers.
21627098 - Fast monitoring of species-specific peptide biomarkers using high intensity focused ult...
8278398 - Topography of a binding site for small amnestic peptides deduced from structure-activit...
15020748 - Crystal structures of a poplar xyloglucan endotransglycosylase reveal details of transg...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  The journal of physical chemistry. A     Volume:  -     ISSN:  1520-5215     ISO Abbreviation:  J Phys Chem A     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9890903     Medline TA:  J Phys Chem A     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Chemistry, Purdue University , West Lafayette, Indiana 47907-2084, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Differential effects of depression and mania symptoms on social adjustment: prospective study in bip...
Next Document:  Deconvolution-based assessment of pituitary GH secretion stimulated with GHRH+arginine in Prader-Wil...