| Speckle variance detection of microvasculature using swept-source optical coherence tomography. | |
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MedLine Citation:
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PMID: 18594688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report on imaging of microcirculation by calculating the speckle variance of optical coherence tomography (OCT) structural images acquired using a Fourier domain mode-locked swept-wavelength laser. The algorithm calculates interframe speckle variance in two-dimensional and three-dimensional OCT data sets and shows little dependence to the Doppler angle ranging from 75 degrees to 90 degrees . We demonstrate in vivo detection of blood flow in vessels as small as 25 microm in diameter in a dorsal skinfold window chamber model with direct comparison with intravital fluorescence confocal microscopy. This technique can visualize vessel-size-dependent vascular shutdown and transient vascular occlusion during Visudyne photodynamic therapy and may provide opportunities for studying therapeutic effects of antivascular treatments without on exogenous contrast agent. |
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Authors:
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Adrian Mariampillai; Beau A Standish; Eduardo H Moriyama; Mamta Khurana; Nigel R Munce; Michael K Leung; James Jiang; Alex Cable; Brian C Wilson; I Alex Vitkin; Victor X D Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Optics letters Volume: 33 ISSN: 0146-9592 ISO Abbreviation: Opt Lett Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-02 Completed Date: 2008-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708433 Medline TA: Opt Lett Country: United States |
Other Details:
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Languages: eng Pagination: 1530-2 Citation Subset: IM |
Affiliation:
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Department of Medical Biophysics, University of Toronto, Toronto, M5G 2M9, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Animals Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods* Mice Mice, Nude Microcirculation / cytology* Microscopy, Confocal / methods* Microscopy, Fluorescence / methods* Reproducibility of Results Sensitivity and Specificity Tomography, Optical Coherence / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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