Document Detail

Specificity and sensitivity of glaucoma detection in the Japanese population using scanning laser polarimetry.
MedLine Citation:
PMID:  11801507     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate the usefulness of the scanning laser polarimeter (GDx; GDx Nerve Fiber Analyzer) for glaucoma detection in the Japanese population, and to investigate the difference in the thickness of retinal nerve fibre layer (RNFL) between normal tension glaucoma (NTG) and primary open angle glaucoma (POAG). METHODS: 69 eyes of 69 normal subjects and 115 eyes of 115 chronic open angle glaucoma patients (60 NTG and 55 POAG patients) were studied. The thickness of RNFL was measured with GDx. An eye was diagnosed as glaucomatous, if at least one original GDx variable showed p <5%. The difference in thickness of RNFL between the NTG and POAG groups was then investigated. RESULTS: 46 normal eyes (66.7%) were diagnosed as not glaucomatous (no variables showing p <5%), and 93 glaucomatous eyes (46 NTG and 47 POAG eyes) (80.9%) were diagnosed as glaucomatous. Actual values of average thickness, ellipse average, superior average, and superior integral were significantly lower in the POAG group than those in the NTG group. CONCLUSIONS: New variables which elucidate focal RNFL defects or early changes are needed to improve the moderate detection ability found in this present study. The pattern of the change in RNFL may differ in NTG and POAG groups.
Shigeo Funaki; Motohiro Shirakashi; Kiyoshi Yaoeda; Haruki Abe; Shiho Kunimatsu; Yasuyuki Suzuki; Goji Tomita; Makoto Araie; Noriko Yamada; Hideya Uchida; Tetsuya Yamamoto; Yoshiaki Kitazawa
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  86     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-21     Completed Date:  2002-02-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  70-4     Citation Subset:  IM    
Department of Ophthalmology, Niigata University School of Medicine, Niigata, Japan.
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MeSH Terms
Aged, 80 and over
Glaucoma / diagnosis*,  physiopathology
Microscopy, Confocal / methods,  standards
Microscopy, Polarization / methods,  standards
Middle Aged
Refractive Errors / etiology,  physiopathology
Regression Analysis
Sensitivity and Specificity
Visual Acuity / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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