| Specificity of the immune response to Haemophilus ducreyi. | |
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MedLine Citation:
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PMID: 8559038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The specificity of the antibody response to Haemophilus ducreyi in sera from patients attending a sexually transmitted disease clinic in South Africa has been studied using immunoblotting. Patients with chancroid were shown to have higher levels of IgG (mean 0.74, SD 0.34) to H. ducreyi than those with no history of chancroid (mean 0.34, SD 0.19). The pattern of the antibody specificity was highly variable between patients with culture proven chancroid but there was no observed strain specificity. In comparison, the patterns obtained using sera from patients without known exposure to H. ducreyi showed less variation between patients and were of less intensity at the dilution used. Sera from patients with chancroid recognised epitopes on proteins that varied in molecular weight between strains, particularly of 60-66kDa (10 of 36 patients) and 25-27kDa (8 of 36 patients). In addition epitopes were recognised on the GroEL and/or DnaK heat shock proteins in 13 of 36 sera tested. There was no apparent change in the epitopes recognised on proteins between the homologous and heterologous strains. Patterns of antibody specificity in sequential sera only varied in one of six patients tested. |
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Authors:
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T J Brown; R C Ballard; C A Ison |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Microbial pathogenesis Volume: 19 ISSN: 0882-4010 ISO Abbreviation: Microb. Pathog. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1996-02-23 Completed Date: 1996-02-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8606191 Medline TA: Microb Pathog Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 31-8 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology, St. Mary's Hospital Medical School, Paddington, London, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Bacterial
/
blood,
immunology* Antibody Specificity Antigens, Bacterial / immunology Chancroid / blood, immunology* Haemophilus ducreyi / immunology*, isolation & purification Humans Immunoblotting Male |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Antigens, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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