Document Detail

Specificity of a human leukocyte neutral proteinase with bovine parathyroid hormone as substrate.
MedLine Citation:
PMID:  6381164     Owner:  NLM     Status:  MEDLINE    
A neutral proteinase, located on the surface of human granulocytes and lymphocytes, degraded bovine parathyroid hormone in vitro. The observed sites of cleavage were between residues 5 and 6 (--ile--gln--), 8 and 9 (--met--his--), 38 and 39 (--gly--ala--) and 41 and 42 (--ile--ala--). Possible physiological implications of these findings are discussed.
P M Barling; K Cartmell; G K Scott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of biochemistry     Volume:  16     ISSN:  0020-711X     ISO Abbreviation:  Int. J. Biochem.     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-09     Completed Date:  1984-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0250365     Medline TA:  Int J Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  815-21     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Amino Acids / analysis
Chromatography, Gel
Chromatography, High Pressure Liquid
Endopeptidases / blood*
Leukocytes / enzymology*
Parathyroid Hormone / metabolism*
Peptide Fragments / analysis
Substrate Specificity
Reg. No./Substance:
0/Amino Acids; 0/Parathyroid Hormone; 0/Peptide Fragments; EC 3.4.-/Endopeptidases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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