| Specificity of a human leukocyte neutral proteinase with bovine parathyroid hormone as substrate. | |
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MedLine Citation:
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PMID: 6381164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A neutral proteinase, located on the surface of human granulocytes and lymphocytes, degraded bovine parathyroid hormone in vitro. The observed sites of cleavage were between residues 5 and 6 (--ile--gln--), 8 and 9 (--met--his--), 38 and 39 (--gly--ala--) and 41 and 42 (--ile--ala--). Possible physiological implications of these findings are discussed. |
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Authors:
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P M Barling; K Cartmell; G K Scott |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The International journal of biochemistry Volume: 16 ISSN: 0020-711X ISO Abbreviation: Int. J. Biochem. Publication Date: 1984 |
Date Detail:
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Created Date: 1984-10-09 Completed Date: 1984-10-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0250365 Medline TA: Int J Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 815-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Amino Acids / analysis Animals Cattle Chromatography, Gel Chromatography, High Pressure Liquid Endopeptidases / blood* Humans Leukocytes / enzymology* Neprilysin Parathyroid Hormone / metabolism* Peptide Fragments / analysis Substrate Specificity |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Parathyroid Hormone; 0/Peptide Fragments; EC 3.4.-/Endopeptidases; EC 3.4.24.11/Neprilysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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