Document Detail

Specificity determinants and diversification of the Brassica self-incompatibility pollen ligand.
MedLine Citation:
PMID:  14694189     Owner:  NLM     Status:  MEDLINE    
Self-incompatibility in crucifers is effected by allele-specific interactions between the highly polymorphic stigmatic S locus receptor kinase (SRK) and its pollen ligand, the S locus cysteine-rich protein (SCR). Here we show that specificity in SCR function is determined by four contiguous amino acids in one variant, indicating that the minimum sequence requirement for gaining a new specificity can be low. We also provide evidence for an extraordinarily high degree of evolutionary flexibility in SCR, whereby SCR can tolerate extensive amino acid changes within the limits of maintaining the same predicted overall structure. This remarkable adaptability suggests a hypothesis for generation of new self-incompatibility specificities by gradual modification of SRK-SCR affinities and, more generally, for functional specialization within families of homologous ligands and receptors.
Thanat Chookajorn; Aardra Kachroo; Daniel R Ripoll; Andrew G Clark; June B Nasrallah
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-12-23
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  101     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-28     Completed Date:  2004-03-30     Revised Date:  2012-06-11    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  911-7     Citation Subset:  IM    
Department of Plant Biology, Cornell Theory Center, Cornell University, Ithaca, NY 14853, USA.
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MeSH Terms
Amino Acid Sequence
Brassica / enzymology,  genetics,  metabolism*
Models, Molecular
Molecular Sequence Data
Plant Proteins
Pollen / metabolism*
Protein Conformation
Protein Kinases / chemistry,  genetics*
Sequence Homology, Amino Acid
Grant Support
Reg. No./Substance:
0/Plant Proteins; EC 2.7.-/Protein Kinases; EC kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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