Document Detail

Specificity of childhood psychotic symptoms for predicting schizophrenia by 38 years of age: a birth cohort study.
MedLine Citation:
PMID:  23302254     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Childhood psychotic symptoms have been used as a subclinical phenotype of schizophrenia in etiological research and as a target for preventative interventions. However, recent studies have cast doubt on the specificity of these symptoms for schizophrenia, suggesting alternative outcomes such as anxiety and depression. Using a prospective longitudinal birth cohort we investigated whether childhood psychotic symptoms predicted a diagnosis of schizophrenia or other psychiatric disorders by 38 years of age.
METHOD: Participants were drawn from a birth cohort of 1037 children from Dunedin, New Zealand, who were followed prospectively to 38 years of age (96% retention rate). Structured clinical interviews were administered at age 11 to assess psychotic symptoms and study members underwent psychiatric assessments at ages 18, 21, 26, 32 and 38 to obtain past-year DSM-III-R/IV diagnoses and self-reports of attempted suicides since adolescence.
RESULTS: Psychotic symptoms at age 11 predicted elevated rates of research diagnoses of schizophrenia and posttraumatic stress disorder (PTSD) and also suicide attempts by age 38, even when controlling for gender, social class and childhood psychopathology. No significant associations were found for persistent anxiety, persistent depression, mania or persistent substance dependence. Very few of the children presenting with age-11 psychotic symptoms were free from disorder by age 38.
CONCLUSIONS: Childhood psychotic symptoms were not specific to a diagnosis of schizophrenia in adulthood and thus future studies of early symptoms should be cautious in extrapolating findings only to this clinical disorder. However, these symptoms may be useful as a marker of adult mental health problems more broadly.
H L Fisher; A Caspi; R Poulton; M H Meier; R Houts; H Harrington; L Arseneault; T E Moffitt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-10
Journal Detail:
Title:  Psychological medicine     Volume:  43     ISSN:  1469-8978     ISO Abbreviation:  Psychol Med     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-08-30     Completed Date:  2014-04-22     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  2077-86     Citation Subset:  IM    
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MeSH Terms
New Zealand / epidemiology
Predictive Value of Tests
Prospective Studies
Psychotic Disorders / epidemiology*
Schizophrenia / epidemiology*
Stress Disorders, Post-Traumatic / epidemiology
Suicide, Attempted / statistics & numerical data
Young Adult
Grant Support
G0601483//Medical Research Council; G0601483//PHS HHS; G1002190//Medical Research Council; G1002366//Medical Research Council; G1002366//PHS HHS; MR/K00381X/1//Medical Research Council; P30 DA023026/DA/NIDA NIH HHS; P30 DA023026/DA/NIDA NIH HHS; R01 AG032282/AG/NIA NIH HHS; R01 HD061298/HD/NICHD NIH HHS

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