| Specificity of cerebellar vermian abnormalities in autism: a quantitative magnetic resonance imaging study. | |
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MedLine Citation:
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PMID: 12940651 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To gain insight into the specificity of cerebellar vermian abnormalities reported in autism, we conducted a magnetic resonance imaging (MRI) study of boys with either of two conditions associated with autism, Down syndrome and fragile X syndrome, compared with boys with idiopathic autism and controls. The subjects, ranging in age from 3 to 9 years, included 16 boys with Down syndrome + autism and 11 boys with Down syndrome only; 13 boys with fragile X syndrome + autism and 9 boys with fragile X syndrome only; 10 boys with idiopathic autism; and 22 controls. Diagnosis of autism was based on DSM-IV criteria, confirmed primarily by the Autism Diagnostic Interview. T1-weighted midsagittal MRIs were used to measure midline structures. Intracranial area, reflecting brain size, was significantly smaller in subjects with Down syndrome. Therefore, all vermian measures were expressed as ratios to intracranial area. Analysis of covariance (covarying for age and IQ) demonstrated that posterior vermi (lobules VI-VII and VIII-X) were markedly smaller in both Down syndrome groups and those with fragile X syndrome only, whereas only lobules VI-VII were reduced in idiopathic autism. Factorial analyses of variance tested interactions between autism factor and the diagnosis of Down syndrome or fragile X syndrome. The size of lobules VI-VII/intracranial area was dependent on autism status only in fragile X syndrome, with ratios significantly larger in fragile X syndrome with autism with respect to fragile X syndrome only. We conclude that selective posterior vermis hypoplasia is seen not only in idiopathic autism but also in Down syndrome and some individuals with fragile X syndrome. However, reductions in vermian lobules VI and VII appear to be specific to idiopathic autism, whereas increased size of lobules VI and VII is associated with autism in fragile X syndrome. The latter results are consistent with MRI studies showing lobules VI-VII hyperplasia in a subset of subjects with idiopathic autism and cerebral and hippocampal enlargements in fragile X syndrome. |
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Authors:
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Walter E Kaufmann; Karen L Cooper; Stewart H Mostofsky; George T Capone; Wendy R Kates; Craig J Newschaffer; Irena Bukelis; Mariah H Stump; Adelene E Jann; Diane C Lanham |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of child neurology Volume: 18 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-08-27 Completed Date: 2003-09-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 463-70 Citation Subset: IM |
Affiliation:
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Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. wekaufma@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autistic Disorder
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physiopathology* Cerebellum / abnormalities*, pathology* Child Down Syndrome / complications, physiopathology* Fragile X Syndrome / complications, physiopathology* Humans Magnetic Resonance Imaging Male |
| Grant Support | |
ID/Acronym/Agency:
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HD 24061/HD/NICHD NIH HHS; HD 33175/HD/NICHD NIH HHS; M01-RR00052/RR/NCRR NIH HHS; NS 02039/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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