Document Detail


Specificity of PGE2 analogs interaction between food intake and antisecretory effect.
MedLine Citation:
PMID:  3099313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the degree of acid suppression that occurred when enprostil, a dehydro-prostaglandin E2 (PGE2) methyl ester analog, was administered before (anti-cibum AC) or after a meal (post-cibum PC). A double-blind, randomized, single-dose, parallel-group design compared enprostil, 35 mcg, 25 min AC or 5 min PC, with placebo AC or PC in 30 healthy adults. Enprostil or placebo was administered at time 0 and a standard beef test meal was ingested at 25 min, followed 5 min later by enprostil or placebo. A second test meal was consumed at 210 min. Intragastric titration was performed from 30 to 390 min. Subjects receiving enprostil-AC or enprostil-PC secreted less (P less than 0.05) acid compared to placebo; however, the antisecretory effects of enprostil-AC or enprostil-PC were similar throughout the duration of study. Minor adverse reactions were present in 13/30 subjects and confined to those receiving enprostil. In contrast to the previously reported potentiation of trimoprostil, a trimethyl-desoxy-PGE2 analog, antisecretory activity by food, enprostil-PC did not result in more prominent or prolonged suppression of gastric acid secretion than enprostil-AC. There is an apparent specificity of different oral PGE2 analogs with regard to their antisecretory activity in the presence or absence of food.
Authors:
R A Levine; S Petokas; L Czarny; G J Schwartz; L Bynum
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  24     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-01-27     Completed Date:  1987-01-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  219-25     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Clinical Trials as Topic
Double-Blind Method
Enprostil
Female
Food*
Gastric Acid / secretion*
Humans
Male
Nausea / chemically induced
Prostaglandins E, Synthetic / administration & dosage,  adverse effects,  pharmacology*
Random Allocation
Vomiting / chemically induced
Grant Support
ID/Acronym/Agency:
RR-229/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Prostaglandins E, Synthetic; 73121-56-9/Enprostil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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