| Specificity of PGE2 analogs interaction between food intake and antisecretory effect. | |
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MedLine Citation:
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PMID: 3099313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the degree of acid suppression that occurred when enprostil, a dehydro-prostaglandin E2 (PGE2) methyl ester analog, was administered before (anti-cibum AC) or after a meal (post-cibum PC). A double-blind, randomized, single-dose, parallel-group design compared enprostil, 35 mcg, 25 min AC or 5 min PC, with placebo AC or PC in 30 healthy adults. Enprostil or placebo was administered at time 0 and a standard beef test meal was ingested at 25 min, followed 5 min later by enprostil or placebo. A second test meal was consumed at 210 min. Intragastric titration was performed from 30 to 390 min. Subjects receiving enprostil-AC or enprostil-PC secreted less (P less than 0.05) acid compared to placebo; however, the antisecretory effects of enprostil-AC or enprostil-PC were similar throughout the duration of study. Minor adverse reactions were present in 13/30 subjects and confined to those receiving enprostil. In contrast to the previously reported potentiation of trimoprostil, a trimethyl-desoxy-PGE2 analog, antisecretory activity by food, enprostil-PC did not result in more prominent or prolonged suppression of gastric acid secretion than enprostil-AC. There is an apparent specificity of different oral PGE2 analogs with regard to their antisecretory activity in the presence or absence of food. |
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Authors:
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R A Levine; S Petokas; L Czarny; G J Schwartz; L Bynum |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and medicine Volume: 24 ISSN: 0262-1746 ISO Abbreviation: Prostaglandins Leukot Med Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1987-01-27 Completed Date: 1987-01-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206868 Medline TA: Prostaglandins Leukot Med Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 219-25 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clinical Trials as Topic Double-Blind Method Enprostil Female Food* Gastric Acid / secretion* Humans Male Nausea / chemically induced Prostaglandins E, Synthetic / administration & dosage, adverse effects, pharmacology* Random Allocation Vomiting / chemically induced |
| Grant Support | |
ID/Acronym/Agency:
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RR-229/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E, Synthetic; 73121-56-9/Enprostil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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