| Specificity of Drosophila cytonemes for distinct signaling pathways. | |
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MedLine Citation:
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PMID: 21493861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytonemes are types of filopodia in the Drosophila wing imaginal disc that are proposed to serve as conduits in which morphogen signaling proteins move between producing and target cells. We investigated the specificity of cytonemes that are made by target cells. Cells in wing discs made cytonemes that responded specifically to Decapentaplegic (Dpp) and cells in eye discs made cytonemes that responded specifically to Spitz (the Drosophila epidermal growth factor protein). Tracheal cells had at least two types: one made in response to Branchless (a Drosophila fibroblast growth factor protein, Bnl), to which they segregate the Bnl receptor, and another to which they segregate the Dpp receptor. We conclude that cells can make several types of cytonemes, each of which responds specifically to a signaling pathway by means of the selective presence of a particular signaling protein receptor that has been localized to that cytoneme. |
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Authors:
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Sougata Roy; Frank Hsiung; Thomas B Kornberg |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 332 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-15 Completed Date: 2011-04-27 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 354-8 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Compound Eye, Arthropod / cytology, growth & development, metabolism Drosophila / cytology, growth & development, metabolism*, ultrastructure* Drosophila Proteins / genetics, metabolism* Epidermal Growth Factor / metabolism Fibroblast Growth Factors / metabolism Heat-Shock Response Hedgehog Proteins / metabolism Larva Ligands Membrane Proteins / metabolism Protein-Serine-Threonine Kinases / genetics, metabolism Protein-Tyrosine Kinases / metabolism Pseudopodia / metabolism*, ultrastructure Receptors, Cell Surface / genetics, metabolism Receptors, Fibroblast Growth Factor / metabolism Recombinant Fusion Proteins / metabolism Signal Transduction* Trachea / cytology, growth & development, metabolism Wing / cytology, growth & development, ultrastructure |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM030637-27/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/Hedgehog Proteins; 0/Ligands; 0/Membrane Proteins; 0/Receptors, Cell Surface; 0/Receptors, Fibroblast Growth Factor; 0/Recombinant Fusion Proteins; 0/branchless protein, Drosophila; 0/dpp protein, Drosophila; 148175-53-5/spi protein, Drosophila; 149291-21-4/hedgehog protein, Drosophila; 62031-54-3/Fibroblast Growth Factors; 62229-50-9/Epidermal Growth Factor; EC 2.7.1.-/tkv protein, Drosophila; EC 2.7.1.112/breathless protein, Drosophila; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
| Comments/Corrections | |
Comment In:
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Science. 2011 Apr 15;332(6027):312-3
[PMID:
21493848
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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