Document Detail

Specific thermographic changes during Walker 256 carcinoma development: differential infrared imaging of tumour, inflammation and haematoma.
MedLine Citation:
PMID:  19232842     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Infrared imaging measures spatial variations in the skin temperature aiming to determine pathological processes; hence possible use of this non-invasive analytical method in cancer detection is emerging. METHODS: Infrared thermal imaging was used to detect changes in rat skin surface temperature associated with experimental cancer development (Walker 256 carcinoma), inflammation (upon s.c. Sephadex injection) and haematoma (provoked by s.c. blood coagulate injection). Infrared camera with a geometric resolution of 76,800 pixels, spectral range of 8-14 microm and the minimal detectable temperature resolution of 0.07 degrees C with spatial resolution of 0.48 mm at measuring distance of 30 cm was used to obtain computerised thermal scans. Genuine ThermoWEB software developed for remote internet control as open source software was used. RESULTS: The raise of peripheral temperature was observed after induction of local inflammation or haematoma. Opposite to that, transient decrease of the skin surface temperature was observed after tumour transplantation. Progressive growth of tumour was associated with the raise of the skin surface temperature from the 10th day after tumour inoculation, when the tumours developed supportive neoangiogenic blood supply, as verified by histology. CONCLUSION: While the raise of peripheral temperature in advanced tumour was caused by neoangiogenesis, the reduction in skin surface temperature in an early period after tumour cell inoculation indicated a decay of transplanted tumour cells due to the immune response and the lack of blood supply. Thus, infrared thermal imaging may have considerable value in evaluation of the tumour development and discrimination of cancer from inflammation and haematoma.
Marija Poljak-Blazi; Darko Kolaric; Morana Jaganjac; Kamelija Zarkovic; Karolj Skala; Neven Zarkovic
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-20
Journal Detail:
Title:  Cancer detection and prevention     Volume:  32     ISSN:  1525-1500     ISO Abbreviation:  Cancer Detect. Prev.     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-03     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704778     Medline TA:  Cancer Detect Prev     Country:  England    
Other Details:
Languages:  eng     Pagination:  431-6     Citation Subset:  IM    
Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.
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MeSH Terms
Carcinoma 256, Walker / blood supply,  pathology*
Hematoma / chemically induced,  pathology*
Inflammation / chemically induced,  pathology*
Infrared Rays*
Neovascularization, Pathologic / diagnosis
Rats, Sprague-Dawley
Regional Blood Flow
Skin / blood supply
Skin Temperature

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