| Specific sites of fatty acid sterol synthesis in isolated skin components. | |
| | |
MedLine Citation:
|
PMID: 5900226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Metabolic studies on isolated mouse skin components were undertaken to determine the specific sites of fatty acid and sterol synthesis. The concentrations of long-chain fatty acids and sterols and the incorporation of radioactivity from acetate-1-(14)C into these lipids are reported for various skin components and intact whole skin. Only fatty acids having chain lengths of 18 carbons or less were produced by the connective tissue cells of the dermis, while fatty acids containing 20 carbons or more, as well as the acids of 18 carbons or less, were synthesized in the upper dermis (papillary reticulum). The upper dermis also produced significant quantities of eicosenoic acid and of an octadecadienoic acid (not linoleic acid), and incorporated labeled acetate into fatty acids containing an odd number of carbons. Removal of the epidermis and adnexa diminished sterol synthesis. However, the upper region of the dermis was capable of synthesizing, from acetate, large quantities of unidentified nonsaponifiable lipids which were neither sterols nor squalene. |
| | |
Authors:
|
S C Brooks; V C Godefroi; W L Simpson |
Related Documents
:
|
3751496 - Effect of phloridzin on lipid biosynthesis by cladosporium tenuissimum cooke. 9171426 - Structural characterization of the lipids a of three bordetella bronchiseptica strains:... 7408846 - Labelling in vivo and in vitro of molecular species of lipids from chloroplast envelope... 17381126 - Lipid characterization of mangrove thraustochytrid--schizochytrium mangrovei. 3196746 - Effect of fatty acid supplementation on cholesterol and retinol esterification in j774 ... 11257526 - Synthesis of (di)adenosine polyphosphates by non-ribosomal peptide synthetases (nrps). |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Journal of lipid research Volume: 7 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1966 Jan |
Date Detail:
|
Created Date: 1966-01-29 Completed Date: 1966-01-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 95-102 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetates
/
metabolism Animals Carbon Isotopes Cholesterol / biosynthesis* Chromatography Fatty Acids / biosynthesis* Mice Palmitic Acids / biosynthesis Skin / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Acetates; 0/Carbon Isotopes; 0/Fatty Acids; 0/Palmitic Acids; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bile acids in the rat: studies in experimental occlusion of the bile duct.
Next Document: Effect of sympathomimetic compounds with beta-adrenergic effects on plasma free fatty acids in man.