Document Detail


Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids.
MedLine Citation:
PMID:  19472314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Our findings identify a specific role for hepatic DGAT1 in esterification of exogenous fatty acids and indicate that DGAT1 contributes to hepatic steatosis induced by this mechanism.
Authors:
Claudio J Villanueva; Mara Monetti; Michelle Shih; Ping Zhou; Steve M Watkins; Sanjay Bhanot; Robert V Farese
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  50     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-08-21     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  434-42     Citation Subset:  IM    
Affiliation:
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94158, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diacylglycerol O-Acyltransferase / deficiency*
Dietary Fats / adverse effects
Fasting / adverse effects
Fatty Acids / administration & dosage,  adverse effects*,  biosynthesis
Fatty Liver / enzymology*,  etiology,  prevention & control
Female
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Oligonucleotides, Antisense / pharmacology
Grant Support
ID/Acronym/Agency:
CO6 RR018928/CO/NCI NIH HHS; F31-DK065312/DK/NIDDK NIH HHS; P30-DK26743/DK/NIDDK NIH HHS; R01 DK056084/DK/NIDDK NIH HHS; R01 DK056084-01A1/DK/NIDDK NIH HHS; R01 DK056084-09/DK/NIDDK NIH HHS; R01-DK056084/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Oligonucleotides, Antisense; EC 2.3.1.20/Dgat1 protein, mouse; EC 2.3.1.20/Diacylglycerol O-Acyltransferase
Comments/Corrections

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