Document Detail

Specific reversal of cytolytic T lymphocyte--target cell interaction.
MedLine Citation:
PMID:  6795359     Owner:  NLM     Status:  MEDLINE    
A functional assay is described that measures the reversal of specific cytolytic T cell (CTL)-target cell binding. Binding of 51Cr-labeled P815 cells was stable in suspension but could be readily reversed by the addition of unlabeled P815 cells. The reversal of CTL-tumor cell and CTL-spleen cell binding was H-2 specific; only cells of the same H-2 type as the bound target cell could induce reversal. In all cases, tumor cells were substantially more efficient than spleen cells in inducing specific reversal.
S P Balk; M F Mescher
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of supramolecular structure and cellular biochemistry     Volume:  16     ISSN:  0275-3723     ISO Abbreviation:  J Supramol Struct Cell Biochem     Publication Date:  1981  
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8106911     Medline TA:  J Supramol Struct Cell Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-52     Citation Subset:  IM    
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MeSH Terms
Calcium / pharmacology
Cytotoxicity, Immunologic*
Magnesium / pharmacology
Mast-Cell Sarcoma / immunology*
Mice, Inbred Strains
Sarcoma, Experimental / immunology
T-Lymphocytes / drug effects,  immunology*
Grant Support
Reg. No./Substance:
7439-95-4/Magnesium; 7440-70-2/Calcium

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