| Specific properties and effect of perindopril in controlling the renin-angiotensin system. | |
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MedLine Citation:
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PMID: 16125051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perindopril is a long-acting, once-daily lipophilic angiotensin-converting enzyme inhibitor with high tissue angiotensin-converting enzyme affinity, lowering angiotensin II and potentiating bradykinin. Its efficacy, safety, and tolerability are well established in the treatment of hypertension and heart failure. Moreover, large morbidity-mortality trials, such as the EUropean trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease (EUROPA) and Perindopril pROtection aGainst REcurrent Stroke Study (PROGRESS), have shown that antihypertensive treatment with perindopril reduces and prevents cardiovascular disease in a large range of patients with vascular diseases, whether or not they are hypertensive. Thus, the outcomes of these and other trials support the concept of cardiovascular protective properties of angiotensin-converting enzyme inhibition with perindopril in addition to the obvious blood-pressure-lowering effect. Considering its properties and the clinical evidence on efficacy and tolerability that has been gathered, perindopril fulfils the criteria of the latest guidelines for hypertension and cardiovascular disease management and should therefore be considered as a first-line antihypertensive agent, forming a consistent part of the comprehensive strategy against hypertension and related cardiovascular complications. |
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Authors:
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R Ferrari; G Pasanisi; P Notarstefano; G Campo; E Gardini; C Ceconi |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of hypertension Volume: 18 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-29 Completed Date: 2006-01-05 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 142S-154S Citation Subset: IM |
Affiliation:
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Division of Cardiology, University Hospital of Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy. fri@dne.unife.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use* Blood Pressure / drug effects Cerebrovascular Disorders / drug therapy Coronary Artery Disease / drug therapy Heart Failure / drug therapy Humans Hypertension / drug therapy Perindopril / therapeutic use* Renin-Angiotensin System / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 82834-16-0/Perindopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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