Document Detail


Specific patterns of allergic sensitization in early childhood and asthma & rhinitis risk.
MedLine Citation:
PMID:  23331564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Specific patterns of allergic sensitization as well as quantification of the in vitro IgE response in early life may provide relevant clinical insight into future rhinitis and asthma risk.
OBJECTIVE: To define relationships among established sensitization to particular aeroallergens, quantitative analyses of allergen-specific IgE levels, pet exposure and sensitization, and asthma and rhinitis risk.
METHODS: Children at high-risk for the development of asthma and allergic diseases were enrolled at birth into the Childhood Origins of ASThma (COAST) study. Allergen-specific IgE was assessed at ages 1, 3, 6, and 9 years by fluoroenzyme immunoassay (Unicap(®) 100; Pharmacia Diagnostics). Current asthma and rhinitis were diagnosed at age 6 and 8 years.
RESULTS: Sensitization to dog was strongly associated with increased asthma risk (P < 0.0001). Sensitization to perennial compared with seasonal allergens was more strongly associated with asthma risk, while sensitization to seasonal allergens was more closely associated with rhinitis risk. Increased levels of specific IgE to perennial allergens were associated with an increased asthma risk (P = 0.05), while any detectable level of IgE to seasonal allergens was associated with increased rhinitis risk (P = 0.0009). While dog and cat sensitization were both independently associated with increased asthma and rhinitis risk, dog exposure at birth was associated with a reduced risk of asthma, regardless of dog sensitization status during the first 6 years of life (P = 0.05).
CONCLUSIONS AND CLINICAL RELEVANCE: Analysing specific patterns of an individual's allergic sensitization profile reveals additional relevant associations with asthma and rhinitis risk as opposed to the information gained from characterizing an individual as 'atopic' by the presence of any demonstrable sensitization alone. Furthermore, protective mechanisms of dog exposure with regards to asthma risk appear to be unrelated to the prevention of sensitization.
Authors:
D J Stoltz; D J Jackson; M D Evans; R E Gangnon; C J Tisler; J E Gern; R F Lemanske
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  43     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-07-01     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  233-41     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology*
Animals
Asthma / immunology*
Cats
Child
Child, Preschool
Dogs
Environmental Exposure
Humans
Hypersensitivity, Immediate / immunology
Immunoglobulin E / blood,  immunology
Infant
Pets
Rhinitis / immunology*
Grant Support
ID/Acronym/Agency:
M01 RR003186/RR/NCRR NIH HHS; M01 RR03186/RR/NCRR NIH HHS; P01 HL070831/HL/NHLBI NIH HHS; P01 HL70831/HL/NHLBI NIH HHS; R01 HL061879/HL/NHLBI NIH HHS; R01 HL61879/HL/NHLBI NIH HHS; T32 AI007635/AI/NIAID NIH HHS; UL1 RR025011/RR/NCRR NIH HHS; UL1 TR000427/TR/NCATS NIH HHS; UL1RR025011/RR/NCRR NIH HHS; UL1TR000427/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E
Comments/Corrections

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