| Specific organized substrates of ventricular fibrillation: Comparison of 320-slice CT heart images in non-ischemic ventricular fibrillation subjects with non-ischemic sustained and non-sustained ventricular tachycardia subjects. | |
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MedLine Citation:
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PMID: 23351787 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: If specific organized substrates of ventricular-fibrillation (VF) are identified, they may provide important-information for prevention of sudden-cardiac-death. To identify specific organized substrates of VF, we compared 320-slice CT heart images in non-ischemic VF subjects with non-ischemic sustained and non-sustained ventricular-tachycardia (VT) subjects. MATERIALS AND METHODS: Retrospective analysis of a total of 103 subjects who had VF (17 subjects; age, 59±16years), sustained VT (20 subjects; 62±19years), or non-sustained VT (66 subjects; 60±15years) underwent 320-slice CT (Aquilion one). RESULTS: After excluding 26 ischemic subjects with >50% stenosis in any coronary arteries on CT, myocardial infarction, or coronary vasospastic angina, a total of 77 non-ischemic subjects (12 VF subjects; age, 58±18years), (13 sustained VT subjects; 55±20years) or (52 non-sustained VT subjects; 58±15years) were analyzed. On CT, myocardial abnormal-late-enhancement was significantly more frequent in the VF group (75%, all myocardial abnormal-late-enhancement in left-ventricle) than in the sustained VT group (31%) and the non-sustained VT group (35%) (both P<0.01). Myocardial fatty change was significantly more frequent in the sustained VT group (54%) than in the VF group (17%) and the non-sustained VT group (12%) (both P<0.01). Final diagnoses of the non-ischemic VF and sustained groups included four subjects in each case with normal cardiac structure on transthoracic echocardiogram; the former included two subjects who had abnormal-late-enhancement on CT without specific ECG findings. CONCLUSIONS: Myocardial abnormal-late-enhancement and fatty change on CT may be substrates of VF or sustained VT in non-ischemic subjects. 320-slice CT can evaluate both coronary arteries and myocardium. |
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Authors:
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Koya Ozawa; Nobusada Funabashi; Hiroyuki Takaoka; Masae Uehara; Yoshio Kobayashi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-22 |
Journal Detail:
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Title: International journal of cardiology Volume: - ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8670, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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