Document Detail

Specific organized substrates of ventricular fibrillation: Comparison of 320-slice CT heart images in non-ischemic ventricular fibrillation subjects with non-ischemic sustained and non-sustained ventricular tachycardia subjects.
MedLine Citation:
PMID:  23351787     Owner:  NLM     Status:  Publisher    
PURPOSE: If specific organized substrates of ventricular-fibrillation (VF) are identified, they may provide important-information for prevention of sudden-cardiac-death. To identify specific organized substrates of VF, we compared 320-slice CT heart images in non-ischemic VF subjects with non-ischemic sustained and non-sustained ventricular-tachycardia (VT) subjects. MATERIALS AND METHODS: Retrospective analysis of a total of 103 subjects who had VF (17 subjects; age, 59±16years), sustained VT (20 subjects; 62±19years), or non-sustained VT (66 subjects; 60±15years) underwent 320-slice CT (Aquilion one). RESULTS: After excluding 26 ischemic subjects with >50% stenosis in any coronary arteries on CT, myocardial infarction, or coronary vasospastic angina, a total of 77 non-ischemic subjects (12 VF subjects; age, 58±18years), (13 sustained VT subjects; 55±20years) or (52 non-sustained VT subjects; 58±15years) were analyzed. On CT, myocardial abnormal-late-enhancement was significantly more frequent in the VF group (75%, all myocardial abnormal-late-enhancement in left-ventricle) than in the sustained VT group (31%) and the non-sustained VT group (35%) (both P<0.01). Myocardial fatty change was significantly more frequent in the sustained VT group (54%) than in the VF group (17%) and the non-sustained VT group (12%) (both P<0.01). Final diagnoses of the non-ischemic VF and sustained groups included four subjects in each case with normal cardiac structure on transthoracic echocardiogram; the former included two subjects who had abnormal-late-enhancement on CT without specific ECG findings. CONCLUSIONS: Myocardial abnormal-late-enhancement and fatty change on CT may be substrates of VF or sustained VT in non-ischemic subjects. 320-slice CT can evaluate both coronary arteries and myocardium.
Koya Ozawa; Nobusada Funabashi; Hiroyuki Takaoka; Masae Uehara; Yoshio Kobayashi
Related Documents :
186217 - Detection of perioperative myocardial damage after coronary artery bypass graft surgery.
15273457 - T wave oversensing in implantable cardioverter defibrillators.
1892077 - Beat-to-beat electrocardiographic morphology variation in healed myocardial infarction.
23313857 - A comparison of etanercept vs. infliximab for the treatment of post-arrest myocardial d...
11676387 - Myocardial infarction following a bee sting.
445717 - Effect of extension of infarction on serial ck activity.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8670, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  MeCP2 modulates gene expression pathways in astrocytes.
Next Document:  T-cell co-stimulation by CD28-CD80/86 and its negative regulator CTLA-4 strongly influence accelerat...