| Specific nutritional support accelerates pressure ulcer healing and reduces wound care intensity in non-malnourished patients. | |
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MedLine Citation:
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PMID: 20598855 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: We investigated the potential of a high-protein, arginine- and micronutrient-enriched oral nutritional supplement (ONS) to improve healing of pressure ulcers in non-malnourished patients who would usually not be considered for extra nutritional support. METHODS: Forty-three non-malnourished subjects with stage III or IV pressure ulcers were included in a multicountry, randomized, controlled, double-blind, parallel group trial. They were offered 200 mL of the specific ONS or a non-caloric control product three times per day, in addition to their regular diet and standard wound care, for a maximum of 8 wk. Results were compared with repeated-measures mixed models (RMMM), analysis of variance, or Fisher's exact tests for categorical parameters. RESULTS: Supplementation with the specific ONS accelerated pressure ulcer healing, indicated by a significantly different decrease in ulcer size compared with the control, over the period of 8 wk (P <or= 0.016, RMMM). The decrease in severity score (Pressure Ulcer Scale for Healing) in the supplemented group differed significantly (P <or= 0.033, RMMM) from the control. Moreover, significantly fewer dressings were required per week in the ONS group compared with the control (P <or= 0.045, RMMM) and less time was spent per week on changing the dressings (P <or= 0.022, RMMM). At the end of the study, blood vitamin C levels had significantly increased in the ONS group compared with the control (P = 0.015, analysis of variance). CONCLUSION: Specific nutritional supplementation accelerated healing of pressure ulcers and decreased wound care intensity in non-malnourished patients, which is likely to decrease overall costs of pressure ulcer treatment. |
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Authors:
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R D van Anholt; L Sobotka; E P Meijer; H Heyman; H W Groen; E Topinková; M van Leen; J M G A Schols |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-07-03 |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 26 ISSN: 1873-1244 ISO Abbreviation: Nutrition Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 867-72 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialised Nutrition, Wageningen, The Netherlands. rogier.vananholt@nutricia.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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