Document Detail

Specific and non-specific nasal provocation tests in children with perennial allergic rhinitis.
MedLine Citation:
PMID:  11834184     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: nasal provocation tests (NPT) have been extensively used in clinical practice to evaluate chronic rhinopathies, mainly allergic rhinitis (AR). METHODS: we submitted 10 perennial AR children (aged from six to 15 years) to histamine (H), Dermatophagoides pteronyssinus (Dp) and Blomia tropicalis (Bt) NPT. All children were sensitized (positive skin prick test, mean wheal > 3 mm) to both mites. Dp and Bt specific NPT were realized in two occasions, apart one week, always preceeded 24 hours by H challenge. Increased concentrations were applied to the nasal mucosa during each NPT: H (0,03 to 16 mg/ml), Dp (1/100,000 to 1 /2.5) and Bt (1/125,000 to 1/10). NPT were evaluated by clinical and rhinomanometric parameters (total score, TS), and by lung function tests. NPT was considered positive, when total nasal resistance (TNR) doubled in relation to basal value. RESULTS: H NPT was positive twice in 8/10 patients. Concordance between H concentration that induces a positive NPT measured by TNR or TS was observed. Regarding to specific NPT, 90 % of patients were positive to Dp and 60 % to Bt. There was no concordance between the allergen concentration that induces a positive SPT and a positive NPT, considering the different concentrations. There were no modification in lung function tests during both specific and non-specific provocation tests. CONCLUSIONS: NPT with H is an objective and reproducible method which allow evaluate nasal reactivity. Specific NPT have restricted indications, mainly when there where doubts about AR's etiology.
B A Barreto; S Daher; C K Naspitz; D Solé
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Publication Detail:
Type:  Comparative Study; Journal Article; Validation Studies    
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  29     ISSN:  0301-0546     ISO Abbreviation:  Allergol Immunopathol (Madr)     Publication Date:    2001 Nov-Dec
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  255-63     Citation Subset:  IM    
Master in Pediatrics, Department of Pediatrics, Universidade Federal de Sao Paulo, Brazil.
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MeSH Terms
Allergens / diagnostic use
Antibody Specificity
Antigens, Dermatophagoides
Glycoproteins / diagnostic use
Histamine / diagnostic use
Immunoglobulin E / blood
Mites / immunology*
Nasal Cavity / immunology
Nasal Provocation Tests / methods*,  standards
Organ Specificity
Reproducibility of Results
Respiratory Function Tests
Rhinitis, Allergic, Perennial / diagnosis*
Sensitivity and Specificity
Skin / immunology
Skin Tests
Species Specificity
Reg. No./Substance:
0/Allergens; 0/Antigens, Dermatophagoides; 0/Glycoproteins; 0/allergen Bt-M; 37341-29-0/Immunoglobulin E; 51-45-6/Histamine

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