Document Detail

Specific mitochondrial DNA deletions in canine myocardial ischemia.
MedLine Citation:
PMID:  8955896     Owner:  NLM     Status:  MEDLINE    
The effect of myocardial ischemia on mitochondrial DNA (mtDNA) structure and the presence of specific mtDNA deletions was determined using the model of Ameroid constriction of canine coronary arteries. The incidence of specific deletions was high in both the endocardial and epicardial tissues perfused by the occluded vessel as compared to myocardial tissues perfused by the unconstricted vessels. Our results show that specific mtDNA deletions similar to the 5 kb and 7.4 kb human mtDNA deletions occur following canine myocardial ischemia. However the presence of these deletions did not correlate with specific mitochondrial enzyme defects.
J Marin-Garcia; M J Goldenthal; R Ananthakrishnan; D Mirvis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemistry and molecular biology international     Volume:  40     ISSN:  1039-9712     ISO Abbreviation:  Biochem. Mol. Biol. Int.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-06     Completed Date:  1997-03-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9306673     Medline TA:  Biochem Mol Biol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  1057-65     Citation Subset:  IM    
Molecular Cardiology Institute, Highland Park, NJ 08904, USA.
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MeSH Terms
Citrate (si)-Synthase / metabolism
DNA Damage*
DNA, Mitochondrial / genetics*
Electron Transport Complex IV / metabolism
Mitochondria, Heart / enzymology,  metabolism*
Myocardial Ischemia / genetics*,  metabolism
Polymerase Chain Reaction
Sequence Deletion
Reg. No./Substance:
0/DNA, Mitochondrial; EC Transport Complex IV; EC (si)-Synthase

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