Document Detail


Specific minor chromosome deletions consistently occurring in myelodysplastic syndromes.
MedLine Citation:
PMID:  3461879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty-two patients with refractory anemia with or without sideroblasts have been investigated cytogenetically one to nine times (mean, 3) over a period of 1-36 months (mean, 16). The initial investigation showed numerical and/or major structural abnormalities [t(3;3), 5q-, -7, or 7q-, 11q-] in nine patients (21%). In addition, minimal terminal deletions were observed in 2p, 8p, 9p, 11p, 12p, 17p, 17q, 20q, and Xp. The detection of these deletions, which have not been reported earlier, was due to consistent application of the high resolution technique, G-banding without trypsin, and metaphase photography on large size negatives. Each deletion occurred as a clone on one or more occasions in 1-17 patients (mean, 7). One or other clonal minimal deletion was observed in 32 patients (76%). Preliminary indirect evidence indicates that alone or together with other factors the deletions promote leukemic transformation of refractory anemia.
Authors:
B Pedersen; G Kerndrup
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  23     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-10-01     Completed Date:  1986-10-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  61-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anemia, Refractory / genetics
Anemia, Refractory, with Excess of Blasts / genetics
Anemia, Sideroblastic / genetics
Chromosome Banding
Chromosome Deletion*
Humans
Karyotyping
Leukemia, Myeloid, Acute / genetics,  pathology
Myelodysplastic Syndromes / classification,  genetics*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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