Document Detail


Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.
MedLine Citation:
PMID:  293686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Use of the specific-locus test to measure the frequency of transmitted gene mutations induced in mouse spermatogonia has shown ethylnitrosourea to be by far the most potent mutagen yet discovered in the mouse. The dose used, 250 mg/kg, gave a mutation rate 5 times as high as had been obtained with 600 R, the most effective acute dose of x-rays. Compared to procarbazine, heretofore the most mutagenic chemical known in the mouse, ethylnitrosourea proved to be 15 times more mutagenic than the peak effect obtained with the most effective dose of procarbazine. Because of its high mutagenicity, ethylnitrosourea can serve as a model compound in exploring the effect of such factors as dose response, dose fractionation, sex, and cell stage on the mutagenic action of a chemical. Ethylnitrosourea is clearly the mutagen of choice for the production of any kind of desired new gene mutations in the mouse.
Authors:
W L Russell; E M Kelly; P R Hunsicker; J W Bangham; S C Maddux; E L Phipps
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  76     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5818-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alleles
Animals
Dose-Response Relationship, Drug
Ethylnitrosourea / pharmacology*
Female
Infertility
Infertility, Male / chemically induced
Male
Mice
Mutagens*
Nitrosourea Compounds / pharmacology*
Spermatogonia / drug effects
Chemical
Reg. No./Substance:
0/Mutagens; 0/Nitrosourea Compounds; 759-73-9/Ethylnitrosourea
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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