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Specific integrins expression is associated with podosome-like structures on Mesodermal Progenitor Cells (MPCs).
MedLine Citation:
PMID:  23379672     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Mesechymal Stromal Cells (MSCs) are a heterogeneous cell population capable of differentiating towards several cell lines in vitro and, possibly, in vivo. Within cultured MSCs we identified and purified a precursor cell population (Mesodermal Progenitor Cells, MPCs) retaining robust proliferation potential and ability to differentiate into endothelial or mesenchymal cells. MPC-derived MSCs retain the ability to further differentiate into osteoblasts, cartilage or fat cells. Here we further characterized MPCs and MSCs by evaluating expression of integrins and adhesion molecules showing their ability to assemble the molecular machinery involved in endothelium adhesion. MPCs were shown to interact with activated and non-activated endothelium whereas MSCs exhibited activation of focal adhesion complexes, higher cell motility, and reduced or absent adhesiveness onto endothelial cells, suggesting a matrix remodeling vocation. We also reported a consistent expression of CXCR4 on the MPC cell surface suggesting that the different phenotypic behavior could be related to specific functions of the cell in each differentiation stage.
Authors:
Simone Pacini; Rita Fazzi; Marina Montali; Vittoria Carnicelli; Edoardo Lazzarini; Mario Petrini
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-5
Journal Detail:
Title:  Stem cells and development     Volume:  -     ISSN:  1557-8534     ISO Abbreviation:  Stem Cells Dev.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197107     Medline TA:  Stem Cells Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Pisa, Oncology and New Advances in Medicine, Pisa, Italy; simone.pacini@do.unipi.it.
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