Document Detail


Specific inhibition of hepatitis C viral gene expression by non-polar (phenylalkyl)phosphonates.
MedLine Citation:
PMID:  14565483     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Different phenylalkyl backbone modified antisense oligonucleotides complementary to the Hepatitis C virus (HCV) RNA nucleotides 326-342 were synthesized. The lipohilic character of modified oligonucleotides was determined from RP-HPLC retention times. The inhibitory effect of these antisense oligonucleotides on HCV gene expression was analyzed in an in vitro test system.
Authors:
S Amberg; A Tamke; W H Caselmann; J W Engels
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  22     ISSN:  1525-7770     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:    2003 May-Aug
Date Detail:
Created Date:  2003-10-20     Completed Date:  2003-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1631-4     Citation Subset:  IM    
Affiliation:
Institute of Organic Chemistry and Chemical Biology, J.W. Goethe University, Frankfurt/Main, Germany. s.amberg@chemie.uni.frankfurt.de
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MeSH Terms
Descriptor/Qualifier:
Base Pair Mismatch / drug effects
Base Sequence
Gene Expression Regulation, Viral / drug effects*
Hepacivirus / drug effects,  genetics*
Indicators and Reagents
Oligodeoxyribonucleotides / pharmacology*
Oligodeoxyribonucleotides, Antisense / chemical synthesis,  pharmacology*
Phosphonic Acids / pharmacology*
Chemical
Reg. No./Substance:
0/Indicators and Reagents; 0/Oligodeoxyribonucleotides; 0/Oligodeoxyribonucleotides, Antisense; 0/Phosphonic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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