Document Detail

Specific hypo-responsive granulomatous tissue reactions in Brugia pahangi-infected jirds.
MedLine Citation:
PMID:  6118035     Owner:  NLM     Status:  MEDLINE    
Two types of experiments were used to study the degree of tissue responsiveness which occurred in Brugia pahangi-infected jirds. In experiment 1, the severity of lymphatic lesions which developed following subcutaneous infection of jirds which has existing intraperitoneal infections was compared to the severity of lymphatic lesions that developed following subcutaneous infection of jirds without previous infections. In experiment 2, comparisons were made of the sizes of granulomas which formed in the lungs around cyanogen bromide-activated Sepharose 4B beads coupled with B. pahangi antigen, which were inoculated intravenously into jirds which: 1. had existing lymphatic infections; 2. were uninfected. Results of both experiments indicated that jirds with intraperitoneal or lymphatic infections of B. pahangi of 120 to 160 days duration were significantly less responsive to B. pahangi or B. pahangi antigens as measured by pathologic tissue reactions than were uninfected jirds. The sizes of granulomas which formed around beads coupled to B. pahangi antigen in noninfected and nonsensitized jirds suggest that this worm material may contain factors which nonspecifically enhance the granulomatous inflammatory reaction.
T R Klei; F M Enright; D P Blanchard; S A Uhl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta tropica     Volume:  38     ISSN:  0001-706X     ISO Abbreviation:  Acta Trop.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370374     Medline TA:  Acta Trop     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  267-76     Citation Subset:  IM    
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MeSH Terms
Antigens / immunology*
Brugia / immunology*
Filariasis / immunology*,  pathology
Filarioidea / immunology*
Granuloma / immunology*,  pathology
Lung Diseases, Parasitic / immunology*,  pathology
Lymph Nodes / pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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