| Specific glycine--accumulating synaptosomes in the spinal cord of rats. | |
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MedLine Citation:
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PMID: 4508336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Subcellular fractionation of rat spinal cord on continuous sucrose density gradients provides evidence for the existence of a specific synaptosomal fraction (enriched in pinched-off nerve endings) that accumulates glycine selectively by way of a high-affinity transport system. The particles in this fraction sediment to a less-dense portion of sucrose gradients than do particles that accumulate neutral, basic, aromatic, and acidic amino acids. Particles accumulating gamma-aminobutyric acid are even less-dense than those storing exogenous glycine. The glycine-specific synaptosomal fraction also exists in the brain stem but not in the cerebral cortex. These findings provide neurochemical support for the suggestion that glycine has a specialized synaptic function, perhaps as neurotransmitter, in mammalian spinal cord. |
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Authors:
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A Arregui; W J Logan; J P Bennett; S H Snyder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 69 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1972 Nov |
Date Detail:
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Created Date: 1973-01-29 Completed Date: 1973-01-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3485-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminobutyric Acids
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metabolism Animals Arginine / metabolism Aspartic Acid / metabolism Brain Stem / cytology, metabolism Carbon Isotopes Cell Fractionation Centrifugation, Density Gradient Cerebral Cortex / cytology, metabolism Glutamates / metabolism Glycine / metabolism* Leucine / metabolism Lysine / metabolism Male Nerve Endings / metabolism* Proline / metabolism Rats Spinal Cord / cytology, metabolism* Subcellular Fractions / metabolism Synaptic Vesicles / metabolism* Synaptosomes / metabolism Threonine / metabolism Tritium Tyrosine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Aminobutyric Acids; 0/Carbon Isotopes; 0/Glutamates; 10028-17-8/Tritium; 147-85-3/Proline; 55520-40-6/Tyrosine; 56-40-6/Glycine; 56-84-8/Aspartic Acid; 56-87-1/Lysine; 61-90-5/Leucine; 72-19-5/Threonine; 74-79-3/Arginine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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