Document Detail


Specific functions for ERK/MAPK signaling during PNS development.
MedLine Citation:
PMID:  21220101     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have established functions of the stimulus-dependent MAPKs, ERK1/2 and ERK5, in DRG, motor neuron, and Schwann cell development. Surprisingly, many aspects of early DRG and motor neuron development were found to be ERK1/2 independent, and Erk5 deletion had no obvious effect on embryonic PNS. In contrast, Erk1/2 deletion in developing neural crest resulted in peripheral nerves that were devoid of Schwann cell progenitors, and deletion of Erk1/2 in Schwann cell precursors caused disrupted differentiation and marked hypomyelination of axons. The Schwann cell phenotypes are similar to those reported in neuregulin-1 and ErbB mutant mice, and neuregulin effects could not be elicited in glial precursors lacking Erk1/2. ERK/MAPK regulation of myelination was specific to Schwann cells, as deletion in oligodendrocyte precursors did not impair myelin formation, but reduced precursor proliferation. Our data suggest a tight linkage between developmental functions of ERK/MAPK signaling and biological actions of specific RTK-activating factors.
Authors:
Jason M Newbern; Xiaoyan Li; Sarah E Shoemaker; Jiang Zhou; Jian Zhong; Yaohong Wu; Daniel Bonder; Steven Hollenback; Giovanni Coppola; Daniel H Geschwind; Gary E Landreth; William D Snider
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  69     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-11     Completed Date:  2011-02-11     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-105     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Western
Cells, Cultured
Extracellular Signal-Regulated MAP Kinases / metabolism
Immunohistochemistry
Mice
Mice, Knockout
Microscopy, Electron
Mitogen-Activated Protein Kinase 3 / deficiency,  genetics,  metabolism*
Mitogen-Activated Protein Kinase 7 / deficiency,  genetics,  metabolism*
Motor Neurons / metabolism,  ultrastructure
Myelin Sheath / ultrastructure*
Neural Crest / growth & development*
Oligodendroglia / metabolism*,  ultrastructure
Peripheral Nervous System / growth & development*
Schwann Cells / metabolism*,  ultrastructure
Signal Transduction / physiology*
Grant Support
ID/Acronym/Agency:
F32 NS061591/NS/NINDS NIH HHS; F32 NS061591-02/NS/NINDS NIH HHS; NS031768/NS/NINDS NIH HHS; P30NS04892/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3; EC 2.7.11.24/Mitogen-Activated Protein Kinase 7
Comments/Corrections

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