Document Detail


Specific factor VIII-related antigen fragmentation: an in vivo and in vitro phenomenon.
MedLine Citation:
PMID:  6180785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Factor VIII concentrates have been shown to have reduced ability to correct the bleeding time defect in von Willebrand's disease and to have abnormal mobility of their VIIIR:Ag on crossed immunoelectrophoresis. This report concerns the partial characterization of a fragment of VIIIR:Ag that lacks some of the normal antigenic determinants present on VIIIR:Ag. It is present in commercial factor VIII concentrates, but not in cryoprecipitate, and is recovered from the plasma of hemophilic patients who have been infused with these concentrates. The fragment is also produced during disseminated intravascular coagulation. Although it has a similar mobility on SDS agarose electrophoresis to the smallest multimer of VIIIR:Ag, they are not immunologically identical.
Authors:
R R Montgomery; J Johnson
Related Documents :
22926255 - Distributions and determinants of mercury concentrations in toenails among american you...
24730565 - Self-control as a moderator of the relationship between drinking identity and alcohol use.
10834295 - Trend in menarcheal age in spain: rural and urban comparison during a recent period.
1505015 - Biosocial factors affecting menarche in a mixed nigerian population.
22396155 - Trends in cause specific mortality across occupations in japanese men of working age du...
24476465 - Are circulating cytokine responses to exercise in the heat augmented in older men?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  60     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  930-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Chemical Fractionation
Disseminated Intravascular Coagulation / blood
Epitopes
Factor VIII / analysis,  immunology,  isolation & purification,  therapeutic use*
Hemophilia A / drug therapy
Humans
Immune Sera
Immunoelectrophoresis, Two-Dimensional
von Willebrand Diseases / drug therapy*
Grant Support
ID/Acronym/Agency:
HL 21730/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Epitopes; 0/Immune Sera; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nonrandom chromosome abnormalities in angioimmunoblastic lymphadenopathy.
Next Document:  Failure of D-thyroxine to increase fetal hemoglobin levels in normal and anemic baboons.