Document Detail

Specific factor VIII-related antigen fragmentation: an in vivo and in vitro phenomenon.
MedLine Citation:
PMID:  6180785     Owner:  NLM     Status:  MEDLINE    
Factor VIII concentrates have been shown to have reduced ability to correct the bleeding time defect in von Willebrand's disease and to have abnormal mobility of their VIIIR:Ag on crossed immunoelectrophoresis. This report concerns the partial characterization of a fragment of VIIIR:Ag that lacks some of the normal antigenic determinants present on VIIIR:Ag. It is present in commercial factor VIII concentrates, but not in cryoprecipitate, and is recovered from the plasma of hemophilic patients who have been infused with these concentrates. The fragment is also produced during disseminated intravascular coagulation. Although it has a similar mobility on SDS agarose electrophoresis to the smallest multimer of VIIIR:Ag, they are not immunologically identical.
R R Montgomery; J Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  60     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  930-9     Citation Subset:  AIM; IM    
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MeSH Terms
Chemical Fractionation
Disseminated Intravascular Coagulation / blood
Factor VIII / analysis,  immunology,  isolation & purification,  therapeutic use*
Hemophilia A / drug therapy
Immune Sera
Immunoelectrophoresis, Two-Dimensional
von Willebrand Diseases / drug therapy*
Grant Support
Reg. No./Substance:
0/Epitopes; 0/Immune Sera; 9001-27-8/Factor VIII

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