| Specific erythroid differentiation of mouse erythroleukemia cells by activins and its enhancement by retinoic acids. | |
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MedLine Citation:
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PMID: 1520319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activin A has been shown to induce hemoglobin production in various hematopoietic cells. Such activities of three structurally distinct activins (activin A, activin AB, and activin B) were compared using F5-5 mouse erythroleukemia cells. Activin A and AB had similarly potent inducing activities whereas that of activin B was much lower. The erythroid inducing activity of activins was suppressed by follistatin, an activin-binding protein but not by inhibin A and inhibin B. Retinoic acids (both all-trans and 13-cis) had weak erythroid differentiation activity. In addition, clear synergistic erythroid induction occurred when retinoic acid and activin A were mixed together. These results indicate that retinoic acid may modulate activin-induced erythropoiesis in vivo. |
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Authors:
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H Uchiyama; M Asashima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 187 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-10-07 Completed Date: 1992-10-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 347-52 Citation Subset: IM |
Affiliation:
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Department of Biology, Yokohama City University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activins Animals Cell Differentiation / drug effects Drug Synergism Erythrocytes / pathology* Follistatin Glycoproteins / pharmacology Humans Inhibins / pharmacology* Leukemia, Erythroblastic, Acute / pathology* Mice Oligopeptides* Peptides / pharmacology Tretinoin / pharmacology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Follistatin; 0/Glycoproteins; 0/Oligopeptides; 0/Peptides; 0/activin B; 104625-48-1/Activins; 137833-32-0/myelopeptides; 302-79-4/Tretinoin; 57285-09-3/Inhibins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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