| Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. | |
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MedLine Citation:
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PMID: 7889569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Taking advantage of the restricted expression of metabotropic glutamate receptor subtype 6 (mGluR6) in retinal ON bipolar cells, we generated knockout mice lacking mGluR6 expression. The homozygous mutant mice showed a loss of ON responses but unchanged OFF responses to light. The mutant mice displayed no obvious changes in retinal cell organization nor in the projection of optic fibers to the brain. Furthermore, the mGluR6-deficient mice showed visual behavioral responses to light stimulation as examined by shuttle box avoidance behavior experiments using light exposure as a conditioned stimulus. The results demonstrate that mGluR6 is essential in synaptic transmission to the ON bipolar cell and that the OFF response provides an important means for transmitting visual information. |
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Authors:
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M Masu; H Iwakabe; Y Tagawa; T Miyoshi; M Yamashita; Y Fukuda; H Sasaki; K Hiroi; Y Nakamura; R Shigemoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell Volume: 80 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-04-14 Completed Date: 1995-04-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 757-65 Citation Subset: IM |
Affiliation:
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Institute for Immunology, Kyoto University Faculty of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Electrophysiology Female Male Mice Mice, Inbred C57BL Mice, Knockout Nerve Fibers / ultrastructure Optic Nerve / ultrastructure Photic Stimulation Receptors, Metabotropic Glutamate / genetics*, physiology Retina / cytology, physiology* Synaptic Transmission / physiology* Vision, Ocular / physiology* Visual Pathways / physiology Visual Perception / physiology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Metabotropic Glutamate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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