Document Detail

Specific changes in type A and B monoamine oxidase activity in different tissues of hypophysectomized rats.
MedLine Citation:
PMID:  6303348     Owner:  NLM     Status:  MEDLINE    
MAO activity was tested in four organs of young male rats 16 days after hypophysectomy. Five monoamines were used as substrates. In the adrenal glands and the thyroid gland MAO activity towards the substrates preferably deaminated by MAO-A was severely decreased. In the adrenal glands, but not in the thyroid gland, the effect of hypophysectomy could be simulated with dexamethasone, a steroid which inhibits ACTH secretion. A significant rise in MAO activity towards substrates for MAO-A and MAO-B occurred in the heart of hypophysectomized rats. There was little change in the MAO activity of whole brain homogenates after hypophysectomy.
M Holzbauer; M B Youdim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  32     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-06-23     Completed Date:  1983-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  469-73     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / enzymology
Adrenocorticotropic Hormone / metabolism
Brain / enzymology
Dexamethasone / pharmacology
Monoamine Oxidase / metabolism*
Rats, Inbred Strains
Thyroid Gland / enzymology
Reg. No./Substance:
50-02-2/Dexamethasone; 9002-60-2/Adrenocorticotropic Hormone; EC Oxidase

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