Document Detail


Specific cardiomyopathy in lupus patients: report of three cases.
MedLine Citation:
PMID:  14769525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinically important myocarditis is an unusual feature in patients with systemic lupus erythematosus (SLE). We report three consecutive lupus patients over a 1 year period who developed severe left ventricular dysfunction in the absence of coronary artery disease or hypertensive cardiomyopathy. Two of them had clinical and biological flare of the disease whereas the lupus was quiescent in the latter. Two of them had positive IgG anticardiolipin antibodies. High dose steroids were given in two patients; one of them also required cyclophosphamide on account of diffuse proliferative glomerulonephritis. Left ventricular function improved quickly and markedly in these two patients; one of them had recurrence of severe myocarditis at intervals of 6 years and was each time responsive to steroids. Lupus cardiomyopathy, a rare event in the course of SLE, can be related to the disease even in the absence of coronary artery disease or hypertensive cardiomyopathy. It may be improved by steroids and immunosuppressive therapy. Literature concerning this cardiac manifestation in lupus is reviewed.
Authors:
Jacques-Eric Gottenberg; Sophie Roux; Patrick Assayag; Didier Clerc; Xavier Mariette
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Joint, bone, spine : revue du rhumatisme     Volume:  71     ISSN:  1297-319X     ISO Abbreviation:  Joint Bone Spine     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-02-10     Completed Date:  2004-05-19     Revised Date:  2006-10-11    
Medline Journal Info:
Nlm Unique ID:  100938016     Medline TA:  Joint Bone Spine     Country:  France    
Other Details:
Languages:  eng     Pagination:  66-9     Citation Subset:  IM    
Affiliation:
Rheumatology department, Hôpital de Bicêtre, (Assistance Publique-Hôpitaux de Paris [AP-HP]), 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre cedex, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies, Anticardiolipin / analysis
Drug Therapy, Combination
Female
Glucocorticoids / therapeutic use
Humans
Immunoglobulin G / blood
Immunosuppressive Agents / therapeutic use
Lupus Erythematosus, Systemic / complications,  drug therapy,  pathology*
Male
Prednisone / therapeutic use
Treatment Outcome
Ventricular Dysfunction, Left / etiology,  immunology,  pathology*
Chemical
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Glucocorticoids; 0/Immunoglobulin G; 0/Immunosuppressive Agents; 53-03-2/Prednisone

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