Document Detail


Specific bile acids inhibit hepatic fatty acid uptake in mice.
MedLine Citation:
PMID:  22531947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: The data demonstrate a novel role for specific bile acids, and the secondary bile acid DCA in particular, in the regulation of hepatic LCFA uptake. The results illuminate a previously unappreciated means by which specific bile acids, such as UDCA and DCA, can impact hepatic triglyceride metabolism and may lead to novel approaches to combat obesity-associated fatty liver disease.
Authors:
Biao Nie; Hyo Min Park; Melissa Kazantzis; Min Lin; Amy Henkin; Stephanie Ng; Sujin Song; Yuli Chen; Heather Tran; Robin Lai; Chris Her; Jacquelyn J Maher; Barry M Forman; Andreas Stahl
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  56     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-05     Completed Date:  2013-01-17     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1300-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / metabolism
Cells, Cultured
Deoxycholic Acid / metabolism,  pharmacology
Disease Models, Animal
Fatty Acid Transport Proteins / drug effects,  metabolism*
Fatty Acids / metabolism*
Hepatocytes / drug effects,  metabolism
Humans
Injections, Subcutaneous
Lipid Metabolism / drug effects
Lithocholic Acid / metabolism,  pharmacology*
Mice
Mice, Inbred Strains
Random Allocation
Real-Time Polymerase Chain Reaction
Sensitivity and Specificity
Ursodeoxycholic Acid / metabolism,  pharmacology*
Grant Support
ID/Acronym/Agency:
DK089202/DK/NIDDK NIH HHS; P30DK026743/DK/NIDDK NIH HHS; R01 DK066336/DK/NIDDK NIH HHS; R01 DK089202/DK/NIDDK NIH HHS; R01DK066336/DK/NIDDK NIH HHS; R56 DK066336/DK/NIDDK NIH HHS; R56DK066336/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Fatty Acid Transport Proteins; 0/Fatty Acids; 0/Slc27a5 protein, mouse; 005990WHZZ/Deoxycholic Acid; 5QU0I8393U/Lithocholic Acid; 724L30Y2QR/Ursodeoxycholic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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