Document Detail


Specific accumulation of organochlorines in human breast milk from Indonesia: levels, distribution, accumulation kinetics and infant health risk.
MedLine Citation:
PMID:  15992976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study determined concentrations of polychlorinated biphenyls (PCBs) and organochlorine compound (OC) pesticides in the milk samples of women from the general population in four locations of Indonesia. The most prevalent residues of OCs were DDTs, PCBs and hexachlorocyclohexane isomers (HCHs), whereas other OCs such as chlordane compounds (CHLs), tris(4-chlorophenyl)methane and hexachlorobenzene were lower. The levels of OCs varied between locations and individuals, with DDTs higher in suburban and rural areas than urban localities, may be due to the differences in food habits and sources between the individuals and locations. Data from Purwakarta site indicated continuing DDT exposure, which may confirm recent usage of DDT in Indonesia. A positive correlation was observed between concentration of OCs in human milk and age of mothers, primiparas women having higher OCs than multiparas, suggesting these parameters play an important role influencing the OC burdens in lactating women. Some individuals accumulated DDTs and HCHs in breast milk close to or even higher than the TDI (tolerable daily intake) guidelines proposed by Health Canada.
Authors:
Agus Sudaryanto; Tatsuya Kunisue; Natsuko Kajiwara; Hisato Iwata; Tussy A Adibroto; Phillipus Hartono; Shinsuke Tanabe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-29
Journal Detail:
Title:  Environmental pollution (Barking, Essex : 1987)     Volume:  139     ISSN:  0269-7491     ISO Abbreviation:  Environ. Pollut.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2006-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804476     Medline TA:  Environ Pollut     Country:  England    
Other Details:
Languages:  eng     Pagination:  107-17     Citation Subset:  IM    
Affiliation:
Center for Marine Environmental Studies, CMES, Ehime University, Matsuyama 790-8577, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Child Development / drug effects
Chlordan / analysis
DDT / analysis
Female
Humans
Hydrocarbons, Chlorinated / analysis*,  pharmacokinetics
Indonesia
Infant
Insecticides / analysis
Isomerism
Lindane / analysis
Milk, Human / chemistry*,  metabolism
Parity
Pesticide Residues / analysis*,  pharmacokinetics
Polychlorinated Biphenyls / analysis*,  pharmacokinetics
Pregnancy
Risk Assessment / methods
Rural Health
Suburban Health
Urban Health
Chemical
Reg. No./Substance:
0/Hydrocarbons, Chlorinated; 0/Insecticides; 0/Pesticide Residues; 0/Polychlorinated Biphenyls; 12789-03-6/Chlordan; 50-29-3/DDT; 58-89-9/Lindane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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